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Exploring Impaired SERCA Pump-Caused Alternation Occurrence in Ischemia
المؤلفون المشاركون
Zang, Yunliang
Liu, Jiaqi
Gong, Yinglan
Zhao, Xiaoye
Zhang, Jucheng
Xia, Ling
المصدر
Computational and Mathematical Methods in Medicine
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-11-12
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Impaired sarcoplasmic reticulum (SR) calcium transport ATPase (SERCA) gives rise to Ca2+ alternans and changes of the Ca2+release amount.
These changes in Ca2+ release amount can reveal the mechanism underlying how the interaction between Ca2+ release and Ca2+ uptake induces Ca2+ alternans.
This study of alternans by calculating the values of Ca2+ release properties with impaired SERCA has not been explored before.
Here, we induced Ca2+ alternans by using an impaired SERCA pump under ischemic conditions.
The results showed that the recruitment and refractoriness of the Ca2+ release increased as Ca2+ alternans occurred.
This indicates triggering Ca waves.
As the propagation of Ca waves is linked to the occurrence of Ca2+ alternans, the “threshold” for Ca waves reflects the key factor in Ca2+ alternans development, and it is still controversial nowadays.
We proposed the ratio between the diastolic network SR (NSR) Ca content (Cansr) and the cytoplasmic Ca content (Cai) (Cansr/Cai) as the “threshold” of Ca waves and Ca2+ alternans.
Diastolic Cansr, Cai, and their ratio were recorded at the onset of Ca2+ alternans.
Compared with certain Cansr and Cai, the “threshold” of the ratio can better explain the comprehensive effects of the Ca2+ release and the Ca2+ uptake on Ca2+ alternans onset.
In addition, these ratios are related with the function of SERCA pumps, which vary with different ischemic conditions.
Thus, values of these ratios could be used to differentiate Ca2+ alternans from different ischemic cases.
This agrees with some experimental results.
Therefore, the certain value of diastolic Cansr/Cai can be the better “threshold” for Ca waves and Ca2+ alternans.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Liu, Jiaqi& Zhao, Xiaoye& Gong, Yinglan& Zhang, Jucheng& Zang, Yunliang& Xia, Ling. 2019. Exploring Impaired SERCA Pump-Caused Alternation Occurrence in Ischemia. Computational and Mathematical Methods in Medicine،Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1130733
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Liu, Jiaqi…[et al.]. Exploring Impaired SERCA Pump-Caused Alternation Occurrence in Ischemia. Computational and Mathematical Methods in Medicine No. 2019 (2019), pp.1-10.
https://search.emarefa.net/detail/BIM-1130733
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Liu, Jiaqi& Zhao, Xiaoye& Gong, Yinglan& Zhang, Jucheng& Zang, Yunliang& Xia, Ling. Exploring Impaired SERCA Pump-Caused Alternation Occurrence in Ischemia. Computational and Mathematical Methods in Medicine. 2019. Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1130733
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1130733
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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