Exploring Impaired SERCA Pump-Caused Alternation Occurrence in Ischemia
Joint Authors
Zang, Yunliang
Liu, Jiaqi
Gong, Yinglan
Zhao, Xiaoye
Zhang, Jucheng
Xia, Ling
Source
Computational and Mathematical Methods in Medicine
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-11-12
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Impaired sarcoplasmic reticulum (SR) calcium transport ATPase (SERCA) gives rise to Ca2+ alternans and changes of the Ca2+release amount.
These changes in Ca2+ release amount can reveal the mechanism underlying how the interaction between Ca2+ release and Ca2+ uptake induces Ca2+ alternans.
This study of alternans by calculating the values of Ca2+ release properties with impaired SERCA has not been explored before.
Here, we induced Ca2+ alternans by using an impaired SERCA pump under ischemic conditions.
The results showed that the recruitment and refractoriness of the Ca2+ release increased as Ca2+ alternans occurred.
This indicates triggering Ca waves.
As the propagation of Ca waves is linked to the occurrence of Ca2+ alternans, the “threshold” for Ca waves reflects the key factor in Ca2+ alternans development, and it is still controversial nowadays.
We proposed the ratio between the diastolic network SR (NSR) Ca content (Cansr) and the cytoplasmic Ca content (Cai) (Cansr/Cai) as the “threshold” of Ca waves and Ca2+ alternans.
Diastolic Cansr, Cai, and their ratio were recorded at the onset of Ca2+ alternans.
Compared with certain Cansr and Cai, the “threshold” of the ratio can better explain the comprehensive effects of the Ca2+ release and the Ca2+ uptake on Ca2+ alternans onset.
In addition, these ratios are related with the function of SERCA pumps, which vary with different ischemic conditions.
Thus, values of these ratios could be used to differentiate Ca2+ alternans from different ischemic cases.
This agrees with some experimental results.
Therefore, the certain value of diastolic Cansr/Cai can be the better “threshold” for Ca waves and Ca2+ alternans.
American Psychological Association (APA)
Liu, Jiaqi& Zhao, Xiaoye& Gong, Yinglan& Zhang, Jucheng& Zang, Yunliang& Xia, Ling. 2019. Exploring Impaired SERCA Pump-Caused Alternation Occurrence in Ischemia. Computational and Mathematical Methods in Medicine،Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1130733
Modern Language Association (MLA)
Liu, Jiaqi…[et al.]. Exploring Impaired SERCA Pump-Caused Alternation Occurrence in Ischemia. Computational and Mathematical Methods in Medicine No. 2019 (2019), pp.1-10.
https://search.emarefa.net/detail/BIM-1130733
American Medical Association (AMA)
Liu, Jiaqi& Zhao, Xiaoye& Gong, Yinglan& Zhang, Jucheng& Zang, Yunliang& Xia, Ling. Exploring Impaired SERCA Pump-Caused Alternation Occurrence in Ischemia. Computational and Mathematical Methods in Medicine. 2019. Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1130733
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1130733