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A Clinical TB Detection Method Based on Molecular Typing Technique with Quality Control
المؤلفون المشاركون
Feng, Tienan
Cheng, Yan
Yu, Suwen
Jiang, Feng
Su, Min
Chen, Jin
المصدر
Computational and Mathematical Methods in Medicine
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-03-25
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
The gold standard for diagnosing pulmonary Mycobacterium tuberculosis (TB) is the detection of tubercle bacillus in patient sputum samples.
However, current methods either require long waiting times to culture the bacteria or have a risk of getting false-positive results due to cross-contamination.
In this study, a method to detect tubercle bacillus based on the molecular typing technique is presented.
This method can detect genetic units, variable number of tandem repeat (VNTR), which are the characteristic of tuberculosis (TB), and performs quality control using a mathematical model, ensuring the reliability of the results.
Compared to other methods, the proposed method was able to process and diagnose a large volume of samples in a run time of six hours, with high sensitivity and specificity.
Our method is also in the pipeline for implementation in clinical testing.
Reliable and confirmed results are stored into a database, and these data are used to further refine the model.
As the volume of data processed from reliable samples increases, the diagnostic power of the model improves.
In addition to improving the quality control scheme, the collected data can be also used to support other TB research, such as that regarding the evolution of the tubercle bacillus.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Feng, Tienan& Cheng, Yan& Yu, Suwen& Jiang, Feng& Su, Min& Chen, Jin. 2019. A Clinical TB Detection Method Based on Molecular Typing Technique with Quality Control. Computational and Mathematical Methods in Medicine،Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1130790
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Feng, Tienan…[et al.]. A Clinical TB Detection Method Based on Molecular Typing Technique with Quality Control. Computational and Mathematical Methods in Medicine No. 2019 (2019), pp.1-10.
https://search.emarefa.net/detail/BIM-1130790
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Feng, Tienan& Cheng, Yan& Yu, Suwen& Jiang, Feng& Su, Min& Chen, Jin. A Clinical TB Detection Method Based on Molecular Typing Technique with Quality Control. Computational and Mathematical Methods in Medicine. 2019. Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1130790
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1130790
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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