A Clinical TB Detection Method Based on Molecular Typing Technique with Quality Control
Joint Authors
Feng, Tienan
Cheng, Yan
Yu, Suwen
Jiang, Feng
Su, Min
Chen, Jin
Source
Computational and Mathematical Methods in Medicine
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-03-25
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The gold standard for diagnosing pulmonary Mycobacterium tuberculosis (TB) is the detection of tubercle bacillus in patient sputum samples.
However, current methods either require long waiting times to culture the bacteria or have a risk of getting false-positive results due to cross-contamination.
In this study, a method to detect tubercle bacillus based on the molecular typing technique is presented.
This method can detect genetic units, variable number of tandem repeat (VNTR), which are the characteristic of tuberculosis (TB), and performs quality control using a mathematical model, ensuring the reliability of the results.
Compared to other methods, the proposed method was able to process and diagnose a large volume of samples in a run time of six hours, with high sensitivity and specificity.
Our method is also in the pipeline for implementation in clinical testing.
Reliable and confirmed results are stored into a database, and these data are used to further refine the model.
As the volume of data processed from reliable samples increases, the diagnostic power of the model improves.
In addition to improving the quality control scheme, the collected data can be also used to support other TB research, such as that regarding the evolution of the tubercle bacillus.
American Psychological Association (APA)
Feng, Tienan& Cheng, Yan& Yu, Suwen& Jiang, Feng& Su, Min& Chen, Jin. 2019. A Clinical TB Detection Method Based on Molecular Typing Technique with Quality Control. Computational and Mathematical Methods in Medicine،Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1130790
Modern Language Association (MLA)
Feng, Tienan…[et al.]. A Clinical TB Detection Method Based on Molecular Typing Technique with Quality Control. Computational and Mathematical Methods in Medicine No. 2019 (2019), pp.1-10.
https://search.emarefa.net/detail/BIM-1130790
American Medical Association (AMA)
Feng, Tienan& Cheng, Yan& Yu, Suwen& Jiang, Feng& Su, Min& Chen, Jin. A Clinical TB Detection Method Based on Molecular Typing Technique with Quality Control. Computational and Mathematical Methods in Medicine. 2019. Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1130790
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1130790