Increased CCR 7 lo PD- 1 hi CXCR 5 + CD 4 + T Cells in Peripheral Blood Mononuclear Cells Are Correlated with Immune Activation in Patients with Chronic HBV Infection
المؤلفون المشاركون
Gao, Zhiliang
Zhao, Qiyi
Xie, Dongying
Huang, Ya-Xin
Wu, Li-Li
Deng, Hong
المصدر
Canadian Journal of Gastroenterology and Hepatology
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-10-08
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
T follicular helper cells (Tfh cells) affect essential immune pathogenesis in chronic hepatitis B virus (HBV) infection.
The CCR 7 l o PD- 1 h i Tfh subset has a partial Tfh effector phenotype and is associated with active Tfh differentiation, whereas the CCR 7 h i PD- 1 l o Tfh subset is a resting phenotype.
We recruited 20 healthy volunteers and 77 patients with chronic HBV infection, including those in the immune tolerant (IT) phase (n=19), immune clearance (IC) phase (n=20), low replicative (LR) phase (n=18), and reactivation (RA) phase (n=20).
The expression of CD4, CXCR5, PD-1, and CCR7 was detected in T cells from peripheral blood by flow cytometry.
The frequency of the CCR 7 l o PD- 1 h i T subset was significantly higher in the patients than in the healthy controls (14.92±4.87% vs 12.23±2.95%, p=0.018).
The frequency of this Tfh subset in the IC group (18.42%±3.08) was increased compared with the IT group (11.94±2.87%, p=0.001) and LR group (13.65±4.93%, p=0.031) and was higher in the RA group than in the IT group (16.03±5.37% vs 11.94±2.87%, p=0.030).
We observed a weak positive correlation between the CCR 7 l o PD- 1 h i Tfh subset population and the alanine transaminase (ALT) level (r=0.370, p=0.001).
The CCR 7 l o PD- 1 h Tfh subset in the chronic HBV-infected patients was elevated to various degrees among the different immune phases.
CCR 7 l o PD- 1 h i CXCR5+CD4+ T cells are correlated with the immune status of chronic HBV infection patients and may be developed as a potential indicator for antiviral treatment.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Huang, Ya-Xin& Zhao, Qiyi& Wu, Li-Li& Xie, Dongying& Gao, Zhiliang& Deng, Hong. 2018. Increased CCR 7 lo PD- 1 hi CXCR 5 + CD 4 + T Cells in Peripheral Blood Mononuclear Cells Are Correlated with Immune Activation in Patients with Chronic HBV Infection. Canadian Journal of Gastroenterology and Hepatology،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1130866
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Huang, Ya-Xin…[et al.]. Increased CCR 7 lo PD- 1 hi CXCR 5 + CD 4 + T Cells in Peripheral Blood Mononuclear Cells Are Correlated with Immune Activation in Patients with Chronic HBV Infection. Canadian Journal of Gastroenterology and Hepatology No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1130866
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Huang, Ya-Xin& Zhao, Qiyi& Wu, Li-Li& Xie, Dongying& Gao, Zhiliang& Deng, Hong. Increased CCR 7 lo PD- 1 hi CXCR 5 + CD 4 + T Cells in Peripheral Blood Mononuclear Cells Are Correlated with Immune Activation in Patients with Chronic HBV Infection. Canadian Journal of Gastroenterology and Hepatology. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1130866
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1130866
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر