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Low Total Dose of Anti-Human T-Lymphocyte Globulin (ATG) Guarantees a Good Glomerular Filtration Rate after Liver Transplant in Recipients with Pretransplant Renal Dysfunction
المؤلفون المشاركون
Dopazo, Cristina
Charco, Ramón
Caralt, Mireia
Pando, Elizabeth
Lázaro, José Luis
Gómez-Gavara, Concepción
Castells, Lluis
Bilbao, Itxarone
المصدر
Canadian Journal of Gastroenterology and Hepatology
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-08-16
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
We aimed to evaluate the safety and efficacy of low doses of anti-T-lymphocyte globulin (ATG)-based immunosuppression in preserving renal function and preventing liver rejection in liver transplant (LT) recipients with pretransplant renal dysfunction.
We designed a prospective single-center cohort study analyzing patients with pre-LT renal dysfunction defined as eGFR<60 mL/min/1.73m2, who underwent induction therapy with ATG (ATG group, n=20).
This group was compared with a similar retrospective cohort treated with basiliximab (BAS group, n=20).
An economic analysis between both induction therapies was also undertaken.
In the ATG group, 45% and 50% of patients had recovered their renal function without acute cellular rejection (ACR) episodes at day 7 and 1 month after LT, respectively, versus 40% and 55% of patients in the BAS group (p=1).
Renal function improved in both groups over time and no differences between groups were observed regarding one-year eGRF and one-year probability of ACR.
Cost per patient of the ATG course was 403€ (r: 126-756) versus 2,524€ of the basiliximab course (p=0.001).
In conclusion, induction with low dose of ATG or basiliximab in patients with pretransplant renal dysfunction is a good strategy for preserving posttransplant renal function; however the use of low-dose ATG resulted in a substantial reduction in drug costs.
This trail is registered with ClinicalTrials.gov number: NCT01453218.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Dopazo, Cristina& Charco, Ramón& Caralt, Mireia& Pando, Elizabeth& Lázaro, José Luis& Gómez-Gavara, Concepción…[et al.]. 2018. Low Total Dose of Anti-Human T-Lymphocyte Globulin (ATG) Guarantees a Good Glomerular Filtration Rate after Liver Transplant in Recipients with Pretransplant Renal Dysfunction. Canadian Journal of Gastroenterology and Hepatology،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1130876
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Dopazo, Cristina…[et al.]. Low Total Dose of Anti-Human T-Lymphocyte Globulin (ATG) Guarantees a Good Glomerular Filtration Rate after Liver Transplant in Recipients with Pretransplant Renal Dysfunction. Canadian Journal of Gastroenterology and Hepatology No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1130876
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Dopazo, Cristina& Charco, Ramón& Caralt, Mireia& Pando, Elizabeth& Lázaro, José Luis& Gómez-Gavara, Concepción…[et al.]. Low Total Dose of Anti-Human T-Lymphocyte Globulin (ATG) Guarantees a Good Glomerular Filtration Rate after Liver Transplant in Recipients with Pretransplant Renal Dysfunction. Canadian Journal of Gastroenterology and Hepatology. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1130876
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1130876
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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