Low Total Dose of Anti-Human T-Lymphocyte Globulin (ATG) Guarantees a Good Glomerular Filtration Rate after Liver Transplant in Recipients with Pretransplant Renal Dysfunction
المؤلفون المشاركون
Dopazo, Cristina
Charco, Ramón
Caralt, Mireia
Pando, Elizabeth
Lázaro, José Luis
Gómez-Gavara, Concepción
Castells, Lluis
Bilbao, Itxarone
المصدر
Canadian Journal of Gastroenterology and Hepatology
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-08-16
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
We aimed to evaluate the safety and efficacy of low doses of anti-T-lymphocyte globulin (ATG)-based immunosuppression in preserving renal function and preventing liver rejection in liver transplant (LT) recipients with pretransplant renal dysfunction.
We designed a prospective single-center cohort study analyzing patients with pre-LT renal dysfunction defined as eGFR<60 mL/min/1.73m2, who underwent induction therapy with ATG (ATG group, n=20).
This group was compared with a similar retrospective cohort treated with basiliximab (BAS group, n=20).
An economic analysis between both induction therapies was also undertaken.
In the ATG group, 45% and 50% of patients had recovered their renal function without acute cellular rejection (ACR) episodes at day 7 and 1 month after LT, respectively, versus 40% and 55% of patients in the BAS group (p=1).
Renal function improved in both groups over time and no differences between groups were observed regarding one-year eGRF and one-year probability of ACR.
Cost per patient of the ATG course was 403€ (r: 126-756) versus 2,524€ of the basiliximab course (p=0.001).
In conclusion, induction with low dose of ATG or basiliximab in patients with pretransplant renal dysfunction is a good strategy for preserving posttransplant renal function; however the use of low-dose ATG resulted in a substantial reduction in drug costs.
This trail is registered with ClinicalTrials.gov number: NCT01453218.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Dopazo, Cristina& Charco, Ramón& Caralt, Mireia& Pando, Elizabeth& Lázaro, José Luis& Gómez-Gavara, Concepción…[et al.]. 2018. Low Total Dose of Anti-Human T-Lymphocyte Globulin (ATG) Guarantees a Good Glomerular Filtration Rate after Liver Transplant in Recipients with Pretransplant Renal Dysfunction. Canadian Journal of Gastroenterology and Hepatology،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1130876
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Dopazo, Cristina…[et al.]. Low Total Dose of Anti-Human T-Lymphocyte Globulin (ATG) Guarantees a Good Glomerular Filtration Rate after Liver Transplant in Recipients with Pretransplant Renal Dysfunction. Canadian Journal of Gastroenterology and Hepatology No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1130876
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Dopazo, Cristina& Charco, Ramón& Caralt, Mireia& Pando, Elizabeth& Lázaro, José Luis& Gómez-Gavara, Concepción…[et al.]. Low Total Dose of Anti-Human T-Lymphocyte Globulin (ATG) Guarantees a Good Glomerular Filtration Rate after Liver Transplant in Recipients with Pretransplant Renal Dysfunction. Canadian Journal of Gastroenterology and Hepatology. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1130876
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1130876
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر