Low Total Dose of Anti-Human T-Lymphocyte Globulin (ATG) Guarantees a Good Glomerular Filtration Rate after Liver Transplant in Recipients with Pretransplant Renal Dysfunction
Joint Authors
Dopazo, Cristina
Charco, Ramón
Caralt, Mireia
Pando, Elizabeth
Lázaro, José Luis
Gómez-Gavara, Concepción
Castells, Lluis
Bilbao, Itxarone
Source
Canadian Journal of Gastroenterology and Hepatology
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-08-16
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
We aimed to evaluate the safety and efficacy of low doses of anti-T-lymphocyte globulin (ATG)-based immunosuppression in preserving renal function and preventing liver rejection in liver transplant (LT) recipients with pretransplant renal dysfunction.
We designed a prospective single-center cohort study analyzing patients with pre-LT renal dysfunction defined as eGFR<60 mL/min/1.73m2, who underwent induction therapy with ATG (ATG group, n=20).
This group was compared with a similar retrospective cohort treated with basiliximab (BAS group, n=20).
An economic analysis between both induction therapies was also undertaken.
In the ATG group, 45% and 50% of patients had recovered their renal function without acute cellular rejection (ACR) episodes at day 7 and 1 month after LT, respectively, versus 40% and 55% of patients in the BAS group (p=1).
Renal function improved in both groups over time and no differences between groups were observed regarding one-year eGRF and one-year probability of ACR.
Cost per patient of the ATG course was 403€ (r: 126-756) versus 2,524€ of the basiliximab course (p=0.001).
In conclusion, induction with low dose of ATG or basiliximab in patients with pretransplant renal dysfunction is a good strategy for preserving posttransplant renal function; however the use of low-dose ATG resulted in a substantial reduction in drug costs.
This trail is registered with ClinicalTrials.gov number: NCT01453218.
American Psychological Association (APA)
Dopazo, Cristina& Charco, Ramón& Caralt, Mireia& Pando, Elizabeth& Lázaro, José Luis& Gómez-Gavara, Concepción…[et al.]. 2018. Low Total Dose of Anti-Human T-Lymphocyte Globulin (ATG) Guarantees a Good Glomerular Filtration Rate after Liver Transplant in Recipients with Pretransplant Renal Dysfunction. Canadian Journal of Gastroenterology and Hepatology،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1130876
Modern Language Association (MLA)
Dopazo, Cristina…[et al.]. Low Total Dose of Anti-Human T-Lymphocyte Globulin (ATG) Guarantees a Good Glomerular Filtration Rate after Liver Transplant in Recipients with Pretransplant Renal Dysfunction. Canadian Journal of Gastroenterology and Hepatology No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1130876
American Medical Association (AMA)
Dopazo, Cristina& Charco, Ramón& Caralt, Mireia& Pando, Elizabeth& Lázaro, José Luis& Gómez-Gavara, Concepción…[et al.]. Low Total Dose of Anti-Human T-Lymphocyte Globulin (ATG) Guarantees a Good Glomerular Filtration Rate after Liver Transplant in Recipients with Pretransplant Renal Dysfunction. Canadian Journal of Gastroenterology and Hepatology. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1130876
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1130876