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Domino Hepatocyte Transplantation: A Therapeutic Alternative for the Treatment of Acute Liver Failure
المؤلفون المشاركون
Pacheco-Moreira, Lúcio F.
Pinto, Marcelo Alves
Cardoso, Liana Monteiro da Fonseca
Alves, Luiz Anastácio
Henriques-Pons, Andrea
المصدر
Canadian Journal of Gastroenterology and Hepatology
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-07-02
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Background and Aims.
Acute liver failure (ALF) is a severe syndrome with an elevated mortality rate, ranging from 40 to 80 %.
Currently, liver transplantation is the only definitive treatment for these patients and new therapies aiming to treat ALF include artificial organs implant and stem cells therapy, for example.
However, a major limitation of liver donors exists.
Living donor liver transplantation (LDLT), split liver transplantation (SLT), and domino liver transplantation (DLT) are some of the available alternatives to treat ALF patients, but these do not reduce the number of patients on waiting lists.
Herein, we discuss domino hepatocyte transplantation (DHT) using livers that would not meet transplantation criteria.
Methods.
We conducted a literature search on PubMed/Medline using acute liver failure, liver transplantation, hepatocyte transplantation, and domino liver transplantation as key words.
Results.
New sources of biochemically functional hepatocytes and therapeutic treatments, in parallel to organ transplantation, may improve liver injury recovery and decrease mortality rates.
Moreover, the literature reports hepatocyte transplantation as a therapeutic alternative for organ shortage.
However, a major challenge remains for a wide clinical application of hepatocytes therapy, i.e., the availability of sufficient amounts of cells for transplantation.
Ideally, hepatocytes isolated from livers rejected for transplantation may be a promising alternative for this problem.
Conclusion.
Our review suggests that DHT may be an excellent strategy to increase cell supplies for hepatocyte transplantation.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Cardoso, Liana Monteiro da Fonseca& Pacheco-Moreira, Lúcio F.& Pinto, Marcelo Alves& Henriques-Pons, Andrea& Alves, Luiz Anastácio. 2018. Domino Hepatocyte Transplantation: A Therapeutic Alternative for the Treatment of Acute Liver Failure. Canadian Journal of Gastroenterology and Hepatology،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1130889
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Cardoso, Liana Monteiro da Fonseca…[et al.]. Domino Hepatocyte Transplantation: A Therapeutic Alternative for the Treatment of Acute Liver Failure. Canadian Journal of Gastroenterology and Hepatology No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1130889
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Cardoso, Liana Monteiro da Fonseca& Pacheco-Moreira, Lúcio F.& Pinto, Marcelo Alves& Henriques-Pons, Andrea& Alves, Luiz Anastácio. Domino Hepatocyte Transplantation: A Therapeutic Alternative for the Treatment of Acute Liver Failure. Canadian Journal of Gastroenterology and Hepatology. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1130889
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1130889
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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