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Domino Hepatocyte Transplantation: A Therapeutic Alternative for the Treatment of Acute Liver Failure
Joint Authors
Pacheco-Moreira, Lúcio F.
Pinto, Marcelo Alves
Cardoso, Liana Monteiro da Fonseca
Alves, Luiz Anastácio
Henriques-Pons, Andrea
Source
Canadian Journal of Gastroenterology and Hepatology
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-07-02
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Background and Aims.
Acute liver failure (ALF) is a severe syndrome with an elevated mortality rate, ranging from 40 to 80 %.
Currently, liver transplantation is the only definitive treatment for these patients and new therapies aiming to treat ALF include artificial organs implant and stem cells therapy, for example.
However, a major limitation of liver donors exists.
Living donor liver transplantation (LDLT), split liver transplantation (SLT), and domino liver transplantation (DLT) are some of the available alternatives to treat ALF patients, but these do not reduce the number of patients on waiting lists.
Herein, we discuss domino hepatocyte transplantation (DHT) using livers that would not meet transplantation criteria.
Methods.
We conducted a literature search on PubMed/Medline using acute liver failure, liver transplantation, hepatocyte transplantation, and domino liver transplantation as key words.
Results.
New sources of biochemically functional hepatocytes and therapeutic treatments, in parallel to organ transplantation, may improve liver injury recovery and decrease mortality rates.
Moreover, the literature reports hepatocyte transplantation as a therapeutic alternative for organ shortage.
However, a major challenge remains for a wide clinical application of hepatocytes therapy, i.e., the availability of sufficient amounts of cells for transplantation.
Ideally, hepatocytes isolated from livers rejected for transplantation may be a promising alternative for this problem.
Conclusion.
Our review suggests that DHT may be an excellent strategy to increase cell supplies for hepatocyte transplantation.
American Psychological Association (APA)
Cardoso, Liana Monteiro da Fonseca& Pacheco-Moreira, Lúcio F.& Pinto, Marcelo Alves& Henriques-Pons, Andrea& Alves, Luiz Anastácio. 2018. Domino Hepatocyte Transplantation: A Therapeutic Alternative for the Treatment of Acute Liver Failure. Canadian Journal of Gastroenterology and Hepatology،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1130889
Modern Language Association (MLA)
Cardoso, Liana Monteiro da Fonseca…[et al.]. Domino Hepatocyte Transplantation: A Therapeutic Alternative for the Treatment of Acute Liver Failure. Canadian Journal of Gastroenterology and Hepatology No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1130889
American Medical Association (AMA)
Cardoso, Liana Monteiro da Fonseca& Pacheco-Moreira, Lúcio F.& Pinto, Marcelo Alves& Henriques-Pons, Andrea& Alves, Luiz Anastácio. Domino Hepatocyte Transplantation: A Therapeutic Alternative for the Treatment of Acute Liver Failure. Canadian Journal of Gastroenterology and Hepatology. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1130889
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1130889