Diagnostic Value of lncRNAs as Biomarker in Hepatocellular Carcinoma: An Updated Meta-Analysis
المؤلفون المشاركون
Chen, Shilian
Zhang, Yaqin
Wu, Xuan
Zhang, Chaoyang
Li, Guancheng
المصدر
Canadian Journal of Gastroenterology and Hepatology
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-10-15
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Some long noncoding RNAs (lncRNAs) display aberrantly high or low expression in hepatocellular carcinoma (HCC) and have the potential to serve as diagnostic biomarkers.
Here, we accomplished a meta-analysis based on current studies to assess the diagnostic value of lncRNAs in HCC.
Eligible literatures were systematically selected from PubMed, Web of Science, and Embase (up to January 20, 2018) according to defined inclusion and exclusion criteria.
QUADAS scale was applied to the quality assessment of the included studies.
Statistical analysis was performed through bivariate random-effects models based on R software.
Publication bias was evaluated by funnel plot and Begg’s and Egger’s tests.
16 articles containing 2,268 cancer patients and 2,574 controls were selected for the final meta-analysis.
Random effect model was used for the meta-analysis due to significant between-study heterogeneity.
The pooled sensitivity, specificity, diagnostic odds ratio (DOR), positive likelihood ratio (PLR), and negative likelihood ratio (NLR) were 0.87(0.838-0.897), 0.829(0.794-0.86), 23.085(20.575-25.901), 4.533(4.239-4.847), and 0.176(0.166-0.186), respectively.
Summary receiver operating characteristic curve (SROC) was conducted to estimate the diagnostic accuracy of lncRNAs in HCC with the area under curve (AUC) of 0.915.
Subgroups analysis showed that lncRNA profiling, sample size, specimen types, and ethnicity might be the sources of heterogeneity.
No publication bias existed according to funnel plot symmetry and Begg’s (P = 0.187) and Egger’s (P = 0.477) tests.
In conclusion, lncRNAs can serve as potential diagnostic biomarkers of HCC with high sensitivity and specificity.
In addition, lncRNAs panel from serum and plasma has a relatively high diagnostic value for HCC patients from Asia.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chen, Shilian& Zhang, Yaqin& Wu, Xuan& Zhang, Chaoyang& Li, Guancheng. 2018. Diagnostic Value of lncRNAs as Biomarker in Hepatocellular Carcinoma: An Updated Meta-Analysis. Canadian Journal of Gastroenterology and Hepatology،Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1131056
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chen, Shilian…[et al.]. Diagnostic Value of lncRNAs as Biomarker in Hepatocellular Carcinoma: An Updated Meta-Analysis. Canadian Journal of Gastroenterology and Hepatology No. 2018 (2018), pp.1-12.
https://search.emarefa.net/detail/BIM-1131056
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chen, Shilian& Zhang, Yaqin& Wu, Xuan& Zhang, Chaoyang& Li, Guancheng. Diagnostic Value of lncRNAs as Biomarker in Hepatocellular Carcinoma: An Updated Meta-Analysis. Canadian Journal of Gastroenterology and Hepatology. 2018. Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1131056
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1131056
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر