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Diagnostic Value of lncRNAs as Biomarker in Hepatocellular Carcinoma: An Updated Meta-Analysis
Joint Authors
Chen, Shilian
Zhang, Yaqin
Wu, Xuan
Zhang, Chaoyang
Li, Guancheng
Source
Canadian Journal of Gastroenterology and Hepatology
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-10-15
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Some long noncoding RNAs (lncRNAs) display aberrantly high or low expression in hepatocellular carcinoma (HCC) and have the potential to serve as diagnostic biomarkers.
Here, we accomplished a meta-analysis based on current studies to assess the diagnostic value of lncRNAs in HCC.
Eligible literatures were systematically selected from PubMed, Web of Science, and Embase (up to January 20, 2018) according to defined inclusion and exclusion criteria.
QUADAS scale was applied to the quality assessment of the included studies.
Statistical analysis was performed through bivariate random-effects models based on R software.
Publication bias was evaluated by funnel plot and Begg’s and Egger’s tests.
16 articles containing 2,268 cancer patients and 2,574 controls were selected for the final meta-analysis.
Random effect model was used for the meta-analysis due to significant between-study heterogeneity.
The pooled sensitivity, specificity, diagnostic odds ratio (DOR), positive likelihood ratio (PLR), and negative likelihood ratio (NLR) were 0.87(0.838-0.897), 0.829(0.794-0.86), 23.085(20.575-25.901), 4.533(4.239-4.847), and 0.176(0.166-0.186), respectively.
Summary receiver operating characteristic curve (SROC) was conducted to estimate the diagnostic accuracy of lncRNAs in HCC with the area under curve (AUC) of 0.915.
Subgroups analysis showed that lncRNA profiling, sample size, specimen types, and ethnicity might be the sources of heterogeneity.
No publication bias existed according to funnel plot symmetry and Begg’s (P = 0.187) and Egger’s (P = 0.477) tests.
In conclusion, lncRNAs can serve as potential diagnostic biomarkers of HCC with high sensitivity and specificity.
In addition, lncRNAs panel from serum and plasma has a relatively high diagnostic value for HCC patients from Asia.
American Psychological Association (APA)
Chen, Shilian& Zhang, Yaqin& Wu, Xuan& Zhang, Chaoyang& Li, Guancheng. 2018. Diagnostic Value of lncRNAs as Biomarker in Hepatocellular Carcinoma: An Updated Meta-Analysis. Canadian Journal of Gastroenterology and Hepatology،Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1131056
Modern Language Association (MLA)
Chen, Shilian…[et al.]. Diagnostic Value of lncRNAs as Biomarker in Hepatocellular Carcinoma: An Updated Meta-Analysis. Canadian Journal of Gastroenterology and Hepatology No. 2018 (2018), pp.1-12.
https://search.emarefa.net/detail/BIM-1131056
American Medical Association (AMA)
Chen, Shilian& Zhang, Yaqin& Wu, Xuan& Zhang, Chaoyang& Li, Guancheng. Diagnostic Value of lncRNAs as Biomarker in Hepatocellular Carcinoma: An Updated Meta-Analysis. Canadian Journal of Gastroenterology and Hepatology. 2018. Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1131056
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1131056