Synthesis, Characterization, Cytotoxic Activity, and Interactions with CT-DNA and BSA of Cationic Ruthenium(II) Complexes Containing Dppm and Quinoline Carboxylates
المؤلفون المشاركون
de Oliveira, Pollyanna Francielli
da Silva, Edinaldo N.
da Silva, Paulo A. B.
Graminha, Angélica E.
Damasceno, Jaqueline L.
Batista, Alzir A.
Von Poelhsitz, Gustavo
Tavares, Denise Crispim
المصدر
Bioinorganic Chemistry and Applications
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-07-26
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
The complexes cis-[Ru(quin)(dppm)2]PF6 and cis-[Ru(kynu)(dppm)2]PF6 (quin = quinaldate; kynu = kynurenate; dppm = bis(diphenylphosphino)methane) were prepared and characterized by elemental analysis, electronic, FTIR, 1H, and 31P{H1} NMR spectroscopies.
Characterization data were consistent with a cis arrangement for the dppm ligands and a bidentate coordination through carboxylate oxygens of the quin and kynu anions.
These complexes were not able to intercalate CT-DNA as shown by circular dichroism spectroscopy.
On the other hand, bovine serum albumin (BSA) binding constants and thermodynamic parameters suggest spontaneous interactions with this protein by hydrogen bonds and van der Waals forces.
Cytotoxicity assays were carried out on a panel of human cancer cell lines including HepG2, MCF-7, and MO59J and one normal cell line GM07492A.
In general, the new ruthenium(II) complexes displayed a moderate to high cytotoxicity in all the assayed cell lines with IC50 ranging from 10.1 to 36 µM and were more cytotoxic than the precursor cis-[RuCl2(dppm)2].
The cis-[Ru(quin)(dppm)2]PF6 were two to three times more active than the reference metallodrug cisplatin in the MCF-7 and MO59J cell lines.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
da Silva, Edinaldo N.& da Silva, Paulo A. B.& Graminha, Angélica E.& de Oliveira, Pollyanna Francielli& Damasceno, Jaqueline L.& Tavares, Denise Crispim…[et al.]. 2017. Synthesis, Characterization, Cytotoxic Activity, and Interactions with CT-DNA and BSA of Cationic Ruthenium(II) Complexes Containing Dppm and Quinoline Carboxylates. Bioinorganic Chemistry and Applications،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1131111
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
da Silva, Edinaldo N.…[et al.]. Synthesis, Characterization, Cytotoxic Activity, and Interactions with CT-DNA and BSA of Cationic Ruthenium(II) Complexes Containing Dppm and Quinoline Carboxylates. Bioinorganic Chemistry and Applications No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1131111
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
da Silva, Edinaldo N.& da Silva, Paulo A. B.& Graminha, Angélica E.& de Oliveira, Pollyanna Francielli& Damasceno, Jaqueline L.& Tavares, Denise Crispim…[et al.]. Synthesis, Characterization, Cytotoxic Activity, and Interactions with CT-DNA and BSA of Cationic Ruthenium(II) Complexes Containing Dppm and Quinoline Carboxylates. Bioinorganic Chemistry and Applications. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1131111
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1131111
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر