Synthesis, Characterization, Cytotoxic Activity, and Interactions with CT-DNA and BSA of Cationic Ruthenium(II) Complexes Containing Dppm and Quinoline Carboxylates
Joint Authors
de Oliveira, Pollyanna Francielli
da Silva, Edinaldo N.
da Silva, Paulo A. B.
Graminha, Angélica E.
Damasceno, Jaqueline L.
Batista, Alzir A.
Von Poelhsitz, Gustavo
Tavares, Denise Crispim
Source
Bioinorganic Chemistry and Applications
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-07-26
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The complexes cis-[Ru(quin)(dppm)2]PF6 and cis-[Ru(kynu)(dppm)2]PF6 (quin = quinaldate; kynu = kynurenate; dppm = bis(diphenylphosphino)methane) were prepared and characterized by elemental analysis, electronic, FTIR, 1H, and 31P{H1} NMR spectroscopies.
Characterization data were consistent with a cis arrangement for the dppm ligands and a bidentate coordination through carboxylate oxygens of the quin and kynu anions.
These complexes were not able to intercalate CT-DNA as shown by circular dichroism spectroscopy.
On the other hand, bovine serum albumin (BSA) binding constants and thermodynamic parameters suggest spontaneous interactions with this protein by hydrogen bonds and van der Waals forces.
Cytotoxicity assays were carried out on a panel of human cancer cell lines including HepG2, MCF-7, and MO59J and one normal cell line GM07492A.
In general, the new ruthenium(II) complexes displayed a moderate to high cytotoxicity in all the assayed cell lines with IC50 ranging from 10.1 to 36 µM and were more cytotoxic than the precursor cis-[RuCl2(dppm)2].
The cis-[Ru(quin)(dppm)2]PF6 were two to three times more active than the reference metallodrug cisplatin in the MCF-7 and MO59J cell lines.
American Psychological Association (APA)
da Silva, Edinaldo N.& da Silva, Paulo A. B.& Graminha, Angélica E.& de Oliveira, Pollyanna Francielli& Damasceno, Jaqueline L.& Tavares, Denise Crispim…[et al.]. 2017. Synthesis, Characterization, Cytotoxic Activity, and Interactions with CT-DNA and BSA of Cationic Ruthenium(II) Complexes Containing Dppm and Quinoline Carboxylates. Bioinorganic Chemistry and Applications،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1131111
Modern Language Association (MLA)
da Silva, Edinaldo N.…[et al.]. Synthesis, Characterization, Cytotoxic Activity, and Interactions with CT-DNA and BSA of Cationic Ruthenium(II) Complexes Containing Dppm and Quinoline Carboxylates. Bioinorganic Chemistry and Applications No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1131111
American Medical Association (AMA)
da Silva, Edinaldo N.& da Silva, Paulo A. B.& Graminha, Angélica E.& de Oliveira, Pollyanna Francielli& Damasceno, Jaqueline L.& Tavares, Denise Crispim…[et al.]. Synthesis, Characterization, Cytotoxic Activity, and Interactions with CT-DNA and BSA of Cationic Ruthenium(II) Complexes Containing Dppm and Quinoline Carboxylates. Bioinorganic Chemistry and Applications. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1131111
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1131111