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Syntheses, Characterization, Resolution, and Biological Studies of Coordination Compounds of Aspartic Acid and Glycine
المؤلفون المشاركون
Aiyelabola, T. O.
Isabirye, D. A.
Akinkunmi, E. O.
Ojo, Isaac
Adebajo, Clement
Obuotor, E. M.
المصدر
Bioinorganic Chemistry and Applications
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-15، 15ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-02-15
دولة النشر
مصر
عدد الصفحات
15
التخصصات الرئيسية
الملخص EN
Enantiomerically enriched coordination compounds of aspartic acid and racemic mixtures of coordination compounds of glycine metal-ligand ratio 1 : 3 were synthesized and characterized using infrared and UV-Vis spectrophotometric techniques and magnetic susceptibility measurements.
Five of the complexes were resolved using (+)-cis-dichlorobis(ethylenediamine)cobalt(III) chloride, (+)-bis(glycinato)(1,10-phenanthroline)cobalt(III) chloride, and (+)-tris(1,10-phenanthroline)nickel(II) chloride as resolving agents.
The antimicrobial and cytotoxic activities of these complexes were then determined.
The results obtained indicated that aspartic acid and glycine coordinated in a bidentate fashion.
The enantiomeric purity of the compounds was in the range of 22.10–32.10%, with (+)-cis-dichlorobis(ethylenediamine)cobalt(III) complex as the more efficient resolving agent.
The resolved complexes exhibited better activity in some cases compared to the parent complexes for both biological activities.
It was therefore inferred that although the increase in the lipophilicity of the complexes may assist in the permeability of the complexes through the cell membrane of the pathogens, the enantiomeric purity of the complexes is also of importance in their activity as antimicrobial and cytotoxic agents.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Aiyelabola, T. O.& Akinkunmi, E. O.& Ojo, Isaac& Obuotor, E. M.& Adebajo, Clement& Isabirye, D. A.. 2017. Syntheses, Characterization, Resolution, and Biological Studies of Coordination Compounds of Aspartic Acid and Glycine. Bioinorganic Chemistry and Applications،Vol. 2017, no. 2017, pp.1-15.
https://search.emarefa.net/detail/BIM-1131121
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Aiyelabola, T. O.…[et al.]. Syntheses, Characterization, Resolution, and Biological Studies of Coordination Compounds of Aspartic Acid and Glycine. Bioinorganic Chemistry and Applications No. 2017 (2017), pp.1-15.
https://search.emarefa.net/detail/BIM-1131121
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Aiyelabola, T. O.& Akinkunmi, E. O.& Ojo, Isaac& Obuotor, E. M.& Adebajo, Clement& Isabirye, D. A.. Syntheses, Characterization, Resolution, and Biological Studies of Coordination Compounds of Aspartic Acid and Glycine. Bioinorganic Chemistry and Applications. 2017. Vol. 2017, no. 2017, pp.1-15.
https://search.emarefa.net/detail/BIM-1131121
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1131121
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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