Syntheses, Characterization, Resolution, and Biological Studies of Coordination Compounds of Aspartic Acid and Glycine
Joint Authors
Aiyelabola, T. O.
Isabirye, D. A.
Akinkunmi, E. O.
Ojo, Isaac
Adebajo, Clement
Obuotor, E. M.
Source
Bioinorganic Chemistry and Applications
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-02-15
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Enantiomerically enriched coordination compounds of aspartic acid and racemic mixtures of coordination compounds of glycine metal-ligand ratio 1 : 3 were synthesized and characterized using infrared and UV-Vis spectrophotometric techniques and magnetic susceptibility measurements.
Five of the complexes were resolved using (+)-cis-dichlorobis(ethylenediamine)cobalt(III) chloride, (+)-bis(glycinato)(1,10-phenanthroline)cobalt(III) chloride, and (+)-tris(1,10-phenanthroline)nickel(II) chloride as resolving agents.
The antimicrobial and cytotoxic activities of these complexes were then determined.
The results obtained indicated that aspartic acid and glycine coordinated in a bidentate fashion.
The enantiomeric purity of the compounds was in the range of 22.10–32.10%, with (+)-cis-dichlorobis(ethylenediamine)cobalt(III) complex as the more efficient resolving agent.
The resolved complexes exhibited better activity in some cases compared to the parent complexes for both biological activities.
It was therefore inferred that although the increase in the lipophilicity of the complexes may assist in the permeability of the complexes through the cell membrane of the pathogens, the enantiomeric purity of the complexes is also of importance in their activity as antimicrobial and cytotoxic agents.
American Psychological Association (APA)
Aiyelabola, T. O.& Akinkunmi, E. O.& Ojo, Isaac& Obuotor, E. M.& Adebajo, Clement& Isabirye, D. A.. 2017. Syntheses, Characterization, Resolution, and Biological Studies of Coordination Compounds of Aspartic Acid and Glycine. Bioinorganic Chemistry and Applications،Vol. 2017, no. 2017, pp.1-15.
https://search.emarefa.net/detail/BIM-1131121
Modern Language Association (MLA)
Aiyelabola, T. O.…[et al.]. Syntheses, Characterization, Resolution, and Biological Studies of Coordination Compounds of Aspartic Acid and Glycine. Bioinorganic Chemistry and Applications No. 2017 (2017), pp.1-15.
https://search.emarefa.net/detail/BIM-1131121
American Medical Association (AMA)
Aiyelabola, T. O.& Akinkunmi, E. O.& Ojo, Isaac& Obuotor, E. M.& Adebajo, Clement& Isabirye, D. A.. Syntheses, Characterization, Resolution, and Biological Studies of Coordination Compounds of Aspartic Acid and Glycine. Bioinorganic Chemistry and Applications. 2017. Vol. 2017, no. 2017, pp.1-15.
https://search.emarefa.net/detail/BIM-1131121
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1131121