Human Genomic Loci Important in Common Infectious Diseases: Role of High-Throughput Sequencing and Genome-Wide Association Studies
المؤلفون المشاركون
Sserwadda, Ivan
Amujal, Marion
Namatovu, Norah
Mboowa, Gerald
المصدر
Canadian Journal of Infectious Diseases and Medical Microbiology
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-03-20
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
HIV/AIDS, tuberculosis (TB), and malaria are 3 major global public health threats that undermine development in many resource-poor settings.
Recently, the notion that positive selection during epidemics or longer periods of exposure to common infectious diseases may have had a major effect in modifying the constitution of the human genome is being interrogated at a large scale in many populations around the world.
This positive selection from infectious diseases increases power to detect associations in genome-wide association studies (GWASs).
High-throughput sequencing (HTS) has transformed both the management of infectious diseases and continues to enable large-scale functional characterization of host resistance/susceptibility alleles and loci; a paradigm shift from single candidate gene studies.
Application of genome sequencing technologies and genomics has enabled us to interrogate the host-pathogen interface for improving human health.
Human populations are constantly locked in evolutionary arms races with pathogens; therefore, identification of common infectious disease-associated genomic variants/markers is important in therapeutic, vaccine development, and screening susceptible individuals in a population.
This review describes a range of host-pathogen genomic loci that have been associated with disease susceptibility and resistant patterns in the era of HTS.
We further highlight potential opportunities for these genetic markers.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Mboowa, Gerald& Sserwadda, Ivan& Amujal, Marion& Namatovu, Norah. 2018. Human Genomic Loci Important in Common Infectious Diseases: Role of High-Throughput Sequencing and Genome-Wide Association Studies. Canadian Journal of Infectious Diseases and Medical Microbiology،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1131132
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Mboowa, Gerald…[et al.]. Human Genomic Loci Important in Common Infectious Diseases: Role of High-Throughput Sequencing and Genome-Wide Association Studies. Canadian Journal of Infectious Diseases and Medical Microbiology No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1131132
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Mboowa, Gerald& Sserwadda, Ivan& Amujal, Marion& Namatovu, Norah. Human Genomic Loci Important in Common Infectious Diseases: Role of High-Throughput Sequencing and Genome-Wide Association Studies. Canadian Journal of Infectious Diseases and Medical Microbiology. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1131132
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1131132
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر