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Human Genomic Loci Important in Common Infectious Diseases: Role of High-Throughput Sequencing and Genome-Wide Association Studies
Joint Authors
Sserwadda, Ivan
Amujal, Marion
Namatovu, Norah
Mboowa, Gerald
Source
Canadian Journal of Infectious Diseases and Medical Microbiology
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-03-20
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
HIV/AIDS, tuberculosis (TB), and malaria are 3 major global public health threats that undermine development in many resource-poor settings.
Recently, the notion that positive selection during epidemics or longer periods of exposure to common infectious diseases may have had a major effect in modifying the constitution of the human genome is being interrogated at a large scale in many populations around the world.
This positive selection from infectious diseases increases power to detect associations in genome-wide association studies (GWASs).
High-throughput sequencing (HTS) has transformed both the management of infectious diseases and continues to enable large-scale functional characterization of host resistance/susceptibility alleles and loci; a paradigm shift from single candidate gene studies.
Application of genome sequencing technologies and genomics has enabled us to interrogate the host-pathogen interface for improving human health.
Human populations are constantly locked in evolutionary arms races with pathogens; therefore, identification of common infectious disease-associated genomic variants/markers is important in therapeutic, vaccine development, and screening susceptible individuals in a population.
This review describes a range of host-pathogen genomic loci that have been associated with disease susceptibility and resistant patterns in the era of HTS.
We further highlight potential opportunities for these genetic markers.
American Psychological Association (APA)
Mboowa, Gerald& Sserwadda, Ivan& Amujal, Marion& Namatovu, Norah. 2018. Human Genomic Loci Important in Common Infectious Diseases: Role of High-Throughput Sequencing and Genome-Wide Association Studies. Canadian Journal of Infectious Diseases and Medical Microbiology،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1131132
Modern Language Association (MLA)
Mboowa, Gerald…[et al.]. Human Genomic Loci Important in Common Infectious Diseases: Role of High-Throughput Sequencing and Genome-Wide Association Studies. Canadian Journal of Infectious Diseases and Medical Microbiology No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1131132
American Medical Association (AMA)
Mboowa, Gerald& Sserwadda, Ivan& Amujal, Marion& Namatovu, Norah. Human Genomic Loci Important in Common Infectious Diseases: Role of High-Throughput Sequencing and Genome-Wide Association Studies. Canadian Journal of Infectious Diseases and Medical Microbiology. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1131132
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1131132