Metal Complexes of a Novel Schiff Base Based on Penicillin: Characterization, Molecular Modeling, and Antibacterial Activity Study
المؤلفون المشاركون
Chaudhary, Narendra Kumar
Mishra, Parashuram
المصدر
Bioinorganic Chemistry and Applications
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-06-08
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
A novel Schiff base ligand of type HL was prepared by the condensation of amoxicillin trihydrate and nicotinaldehyde.
The metal complexes of Co+2, Ni+2, Cu+2, and Zn+2 were characterized and investigated by physical and spectral techniques, namely, elemental analysis, melting point, conductivity, 1H NMR, IR, UV-Vis spectra, ESR, SEM, and mass spectrometry measurements.
They were further analyzed by thermal technique (TGA/DTA) to gain better insight about the thermal stability and kinetic properties of the complexes.
Thermal data revealed high thermal stability and nonspontaneous nature of the decomposition steps.
The Coats-Redfern method was applied to extract thermodynamic parameters to explain the kinetic behavior.
The molar conductance values were relatively low, showing their nonelectrolytic nature.
The powder XRD pattern revealed amorphous nature except copper complex (1c) that crystallized in the triclinic crystal system.
The EPR study strongly recommends the tetrahedral geometry of 1c.
The structure optimization by MM force field calculation through ArgusLab 4.0.1 software program supports the concerned geometry of the complexes.
The in vitro antibacterial activity of all the compounds, at their two different concentrations, was screened against four bacterial pathogens, namely, E.
coli, P.
vulgaris, K.
pneumoniae, and S.
aureus, and showed better activity compared to parent drug and control drug.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chaudhary, Narendra Kumar& Mishra, Parashuram. 2017. Metal Complexes of a Novel Schiff Base Based on Penicillin: Characterization, Molecular Modeling, and Antibacterial Activity Study. Bioinorganic Chemistry and Applications،Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1131157
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chaudhary, Narendra Kumar& Mishra, Parashuram. Metal Complexes of a Novel Schiff Base Based on Penicillin: Characterization, Molecular Modeling, and Antibacterial Activity Study. Bioinorganic Chemistry and Applications No. 2017 (2017), pp.1-13.
https://search.emarefa.net/detail/BIM-1131157
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chaudhary, Narendra Kumar& Mishra, Parashuram. Metal Complexes of a Novel Schiff Base Based on Penicillin: Characterization, Molecular Modeling, and Antibacterial Activity Study. Bioinorganic Chemistry and Applications. 2017. Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1131157
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1131157
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر