Metal Complexes of a Novel Schiff Base Based on Penicillin: Characterization, Molecular Modeling, and Antibacterial Activity Study
Joint Authors
Chaudhary, Narendra Kumar
Mishra, Parashuram
Source
Bioinorganic Chemistry and Applications
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-06-08
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
A novel Schiff base ligand of type HL was prepared by the condensation of amoxicillin trihydrate and nicotinaldehyde.
The metal complexes of Co+2, Ni+2, Cu+2, and Zn+2 were characterized and investigated by physical and spectral techniques, namely, elemental analysis, melting point, conductivity, 1H NMR, IR, UV-Vis spectra, ESR, SEM, and mass spectrometry measurements.
They were further analyzed by thermal technique (TGA/DTA) to gain better insight about the thermal stability and kinetic properties of the complexes.
Thermal data revealed high thermal stability and nonspontaneous nature of the decomposition steps.
The Coats-Redfern method was applied to extract thermodynamic parameters to explain the kinetic behavior.
The molar conductance values were relatively low, showing their nonelectrolytic nature.
The powder XRD pattern revealed amorphous nature except copper complex (1c) that crystallized in the triclinic crystal system.
The EPR study strongly recommends the tetrahedral geometry of 1c.
The structure optimization by MM force field calculation through ArgusLab 4.0.1 software program supports the concerned geometry of the complexes.
The in vitro antibacterial activity of all the compounds, at their two different concentrations, was screened against four bacterial pathogens, namely, E.
coli, P.
vulgaris, K.
pneumoniae, and S.
aureus, and showed better activity compared to parent drug and control drug.
American Psychological Association (APA)
Chaudhary, Narendra Kumar& Mishra, Parashuram. 2017. Metal Complexes of a Novel Schiff Base Based on Penicillin: Characterization, Molecular Modeling, and Antibacterial Activity Study. Bioinorganic Chemistry and Applications،Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1131157
Modern Language Association (MLA)
Chaudhary, Narendra Kumar& Mishra, Parashuram. Metal Complexes of a Novel Schiff Base Based on Penicillin: Characterization, Molecular Modeling, and Antibacterial Activity Study. Bioinorganic Chemistry and Applications No. 2017 (2017), pp.1-13.
https://search.emarefa.net/detail/BIM-1131157
American Medical Association (AMA)
Chaudhary, Narendra Kumar& Mishra, Parashuram. Metal Complexes of a Novel Schiff Base Based on Penicillin: Characterization, Molecular Modeling, and Antibacterial Activity Study. Bioinorganic Chemistry and Applications. 2017. Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1131157
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1131157