A Hyperfluorinated Hydrophilic Molecule for Aqueous 19F MRI Contrast Media

المؤلفون المشاركون

Tanifum, Eric A.
Devkota, Laxman
Ngwa, Conelius
Badachhape, Andrew A.
Ghaghada, Ketan B.
Romero, Jonathan
Pautler, Robia G.
Annapragada, Ananth V.

المصدر

Contrast Media & Molecular Imaging

العدد

المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-8، 8ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2018-11-12

دولة النشر

مصر

عدد الصفحات

8

التخصصات الرئيسية

الأمراض
الطب البشري

الملخص EN

Fluorine-19 (19F) magnetic resonance imaging (MRI) has the potential for a wide range of in vivo applications but is limited by lack of flexibility in exogenous probe formulation.

Most 19F MRI probes are composed of perfluorocarbons (PFCs) or perfluoropolyethers (PFPEs) with intrinsic properties which limit formulation options.

Hydrophilic organofluorine molecules can provide more flexibility in formulation options.

We report herein a hyperfluorinated hydrophilic organoflourine, ET1084, with ∼24 wt.

% 19F content.

It dissolves in water and aqueous buffers to give solutions with ≥8 M 19F.

19F MRI phantom studies at 9.4T employing a 10-minute multislice multiecho (MSME) scan sequence show a linear increase in signal-to-noise ratio (SNR) with increasing concentrations of the molecule and a detection limit of 5 mM.

Preliminary cytotoxicity and genotoxicity assessments suggest it is safe at concentrations of up to 20 mM.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Tanifum, Eric A.& Devkota, Laxman& Ngwa, Conelius& Badachhape, Andrew A.& Ghaghada, Ketan B.& Romero, Jonathan…[et al.]. 2018. A Hyperfluorinated Hydrophilic Molecule for Aqueous 19F MRI Contrast Media. Contrast Media & Molecular Imaging،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1131293

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Tanifum, Eric A.…[et al.]. A Hyperfluorinated Hydrophilic Molecule for Aqueous 19F MRI Contrast Media. Contrast Media & Molecular Imaging No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1131293

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Tanifum, Eric A.& Devkota, Laxman& Ngwa, Conelius& Badachhape, Andrew A.& Ghaghada, Ketan B.& Romero, Jonathan…[et al.]. A Hyperfluorinated Hydrophilic Molecule for Aqueous 19F MRI Contrast Media. Contrast Media & Molecular Imaging. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1131293

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1131293