A Hyperfluorinated Hydrophilic Molecule for Aqueous 19F MRI Contrast Media
Joint Authors
Tanifum, Eric A.
Devkota, Laxman
Ngwa, Conelius
Badachhape, Andrew A.
Ghaghada, Ketan B.
Romero, Jonathan
Pautler, Robia G.
Annapragada, Ananth V.
Source
Contrast Media & Molecular Imaging
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-11-12
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Fluorine-19 (19F) magnetic resonance imaging (MRI) has the potential for a wide range of in vivo applications but is limited by lack of flexibility in exogenous probe formulation.
Most 19F MRI probes are composed of perfluorocarbons (PFCs) or perfluoropolyethers (PFPEs) with intrinsic properties which limit formulation options.
Hydrophilic organofluorine molecules can provide more flexibility in formulation options.
We report herein a hyperfluorinated hydrophilic organoflourine, ET1084, with ∼24 wt.
% 19F content.
It dissolves in water and aqueous buffers to give solutions with ≥8 M 19F.
19F MRI phantom studies at 9.4T employing a 10-minute multislice multiecho (MSME) scan sequence show a linear increase in signal-to-noise ratio (SNR) with increasing concentrations of the molecule and a detection limit of 5 mM.
Preliminary cytotoxicity and genotoxicity assessments suggest it is safe at concentrations of up to 20 mM.
American Psychological Association (APA)
Tanifum, Eric A.& Devkota, Laxman& Ngwa, Conelius& Badachhape, Andrew A.& Ghaghada, Ketan B.& Romero, Jonathan…[et al.]. 2018. A Hyperfluorinated Hydrophilic Molecule for Aqueous 19F MRI Contrast Media. Contrast Media & Molecular Imaging،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1131293
Modern Language Association (MLA)
Tanifum, Eric A.…[et al.]. A Hyperfluorinated Hydrophilic Molecule for Aqueous 19F MRI Contrast Media. Contrast Media & Molecular Imaging No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1131293
American Medical Association (AMA)
Tanifum, Eric A.& Devkota, Laxman& Ngwa, Conelius& Badachhape, Andrew A.& Ghaghada, Ketan B.& Romero, Jonathan…[et al.]. A Hyperfluorinated Hydrophilic Molecule for Aqueous 19F MRI Contrast Media. Contrast Media & Molecular Imaging. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1131293
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1131293