In Vivo 6-([18F]Fluoroacetamido)-1-hexanoicanilide PET Imaging of Altered Histone Deacetylase Activity in Chemotherapy-Induced Neurotoxicity
المؤلفون المشاركون
Fukumitsu, Nobuyoshi
Jeong, Hwan-Jeong
Gelovani, Juri G.
Flores II, Leo Garcia
Mukhopadhyay, Uday
Young, Daniel
Tong, William
Yeh, Skye Hsin-Hsien
Ogawa, Kazuma
المصدر
Contrast Media & Molecular Imaging
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-03-20
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Background.
Histone deacetylases (HDACs) regulate gene expression by changing histone deacetylation status.
Neurotoxicity is one of the major side effects of cisplatin, which reacts with deoxyribonucleic acid (DNA) and has excellent antitumor effects.
Suberoylanilide hydroxamic acid (SAHA) is an HDAC inhibitor with neuroprotective effects against cisplatin-induced neurotoxicity.
Purpose.
We investigated how cisplatin with and without SAHA pretreatment affects HDAC expression/activity in the brain by using 6-([18F]fluoroacetamido)-1-hexanoicanilide ([18F]FAHA) as a positron emission tomography (PET) imaging agent for HDAC IIa.
Materials and Methods.
[18F]FAHA and [18F]fluoro-2-deoxy-2-D-glucose ([18F]FDG) PET studies were done in 24 mice on 2 consecutive days and again 1 week later.
The mice were divided into three groups according to drug administration between the first and second imaging sessions (Group A: cisplatin 2 mg/kg, twice; Group B: cisplatin 4 mg/kg, twice; Group C: cisplatin 4 mg/kg, twice, and SAHA 300 mg/kg pretreatment, 4 times).
Results.
The K i value of [18F]FAHA was increased and the percentage of injected dose/tissue g (% ID/g) of [18F]FDG was decreased in the brains of animals in Groups A and B.
The K i value of [18F]FAHA and % ID/g of [18F]FDG were not significantly different in Group C.
Conclusions.
[18F]FAHA PET clearly showed increased HDAC activity suggestive of cisplatin neurotoxicity in vivo, which was blocked by SAHA pretreatment.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Fukumitsu, Nobuyoshi& Yeh, Skye Hsin-Hsien& Flores II, Leo Garcia& Mukhopadhyay, Uday& Young, Daniel& Ogawa, Kazuma…[et al.]. 2018. In Vivo 6-([18F]Fluoroacetamido)-1-hexanoicanilide PET Imaging of Altered Histone Deacetylase Activity in Chemotherapy-Induced Neurotoxicity. Contrast Media & Molecular Imaging،Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1131366
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Fukumitsu, Nobuyoshi…[et al.]. In Vivo 6-([18F]Fluoroacetamido)-1-hexanoicanilide PET Imaging of Altered Histone Deacetylase Activity in Chemotherapy-Induced Neurotoxicity. Contrast Media & Molecular Imaging No. 2018 (2018), pp.1-12.
https://search.emarefa.net/detail/BIM-1131366
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Fukumitsu, Nobuyoshi& Yeh, Skye Hsin-Hsien& Flores II, Leo Garcia& Mukhopadhyay, Uday& Young, Daniel& Ogawa, Kazuma…[et al.]. In Vivo 6-([18F]Fluoroacetamido)-1-hexanoicanilide PET Imaging of Altered Histone Deacetylase Activity in Chemotherapy-Induced Neurotoxicity. Contrast Media & Molecular Imaging. 2018. Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1131366
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1131366
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر