Assessment of Liver Function Using Pharmacokinetic Parameters of Gd-EOB-DTPA: Experimental Study in Rat Hepatectomy Model
المؤلفون المشاركون
Kim, Kyung Won
You, Myung-Won
Kim, Hyoung Jung
Lim, Hyeong-Seok
Kim, So Yeon
Byun, Jae Ho
Hwang, Dae Wook
Lee, Young-Joo
المصدر
Contrast Media & Molecular Imaging
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-03-11
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Objectives.
To determine whether the pharmacokinetic parameters of Gd-EOB-DTPA can identify the difference in liver function in a rat hepatectomy model.
Methods.
A total of 56 eight-week-old male Sprague-Dawley rats were divided into the following groups: control group without hepatectomy (n=16), 70% hepatectomy group (n=14), and 90% hepatectomy group (n=26).
On postoperative day 2, Gd-EOB-DTPA (0.1 mmol/kg) was injected intravenously and serial blood samples were obtained.
Pharmacokinetic analysis was performed using a noncompartmental method.
Statistical analysis was performed using one-way analysis of variance and post hoc pairwise group comparisons.
Results.
After excluding 6 rats that died unexpectedly, blood samples were obtained from 16, 14, and 20 rats in the control group, 70% hepatectomy group, and 90% hepatectomy group.
There was a significant increase in area under the concentration-time curve from time zero to the time of the last measurable concentration between the 70% and 90% hepatectomy group (P<0.001).
The volume of distribution at steady state was significantly decreased between the control and 70% hepatectomy group (P<0.001).
The clearance was significantly different in all pairwise group comparisons (P<0.001).
Conclusions.
The vascular clearance of Gd-EOB-DTPA can identify the difference in liver function in a rat hepatectomy model.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
You, Myung-Won& Kim, Hyoung Jung& Lim, Hyeong-Seok& Kim, So Yeon& Byun, Jae Ho& Kim, Kyung Won…[et al.]. 2018. Assessment of Liver Function Using Pharmacokinetic Parameters of Gd-EOB-DTPA: Experimental Study in Rat Hepatectomy Model. Contrast Media & Molecular Imaging،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1131486
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
You, Myung-Won…[et al.]. Assessment of Liver Function Using Pharmacokinetic Parameters of Gd-EOB-DTPA: Experimental Study in Rat Hepatectomy Model. Contrast Media & Molecular Imaging No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1131486
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
You, Myung-Won& Kim, Hyoung Jung& Lim, Hyeong-Seok& Kim, So Yeon& Byun, Jae Ho& Kim, Kyung Won…[et al.]. Assessment of Liver Function Using Pharmacokinetic Parameters of Gd-EOB-DTPA: Experimental Study in Rat Hepatectomy Model. Contrast Media & Molecular Imaging. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1131486
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1131486
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر