Assessment of Liver Function Using Pharmacokinetic Parameters of Gd-EOB-DTPA: Experimental Study in Rat Hepatectomy Model
Joint Authors
Kim, Kyung Won
You, Myung-Won
Kim, Hyoung Jung
Lim, Hyeong-Seok
Kim, So Yeon
Byun, Jae Ho
Hwang, Dae Wook
Lee, Young-Joo
Source
Contrast Media & Molecular Imaging
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-03-11
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Objectives.
To determine whether the pharmacokinetic parameters of Gd-EOB-DTPA can identify the difference in liver function in a rat hepatectomy model.
Methods.
A total of 56 eight-week-old male Sprague-Dawley rats were divided into the following groups: control group without hepatectomy (n=16), 70% hepatectomy group (n=14), and 90% hepatectomy group (n=26).
On postoperative day 2, Gd-EOB-DTPA (0.1 mmol/kg) was injected intravenously and serial blood samples were obtained.
Pharmacokinetic analysis was performed using a noncompartmental method.
Statistical analysis was performed using one-way analysis of variance and post hoc pairwise group comparisons.
Results.
After excluding 6 rats that died unexpectedly, blood samples were obtained from 16, 14, and 20 rats in the control group, 70% hepatectomy group, and 90% hepatectomy group.
There was a significant increase in area under the concentration-time curve from time zero to the time of the last measurable concentration between the 70% and 90% hepatectomy group (P<0.001).
The volume of distribution at steady state was significantly decreased between the control and 70% hepatectomy group (P<0.001).
The clearance was significantly different in all pairwise group comparisons (P<0.001).
Conclusions.
The vascular clearance of Gd-EOB-DTPA can identify the difference in liver function in a rat hepatectomy model.
American Psychological Association (APA)
You, Myung-Won& Kim, Hyoung Jung& Lim, Hyeong-Seok& Kim, So Yeon& Byun, Jae Ho& Kim, Kyung Won…[et al.]. 2018. Assessment of Liver Function Using Pharmacokinetic Parameters of Gd-EOB-DTPA: Experimental Study in Rat Hepatectomy Model. Contrast Media & Molecular Imaging،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1131486
Modern Language Association (MLA)
You, Myung-Won…[et al.]. Assessment of Liver Function Using Pharmacokinetic Parameters of Gd-EOB-DTPA: Experimental Study in Rat Hepatectomy Model. Contrast Media & Molecular Imaging No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1131486
American Medical Association (AMA)
You, Myung-Won& Kim, Hyoung Jung& Lim, Hyeong-Seok& Kim, So Yeon& Byun, Jae Ho& Kim, Kyung Won…[et al.]. Assessment of Liver Function Using Pharmacokinetic Parameters of Gd-EOB-DTPA: Experimental Study in Rat Hepatectomy Model. Contrast Media & Molecular Imaging. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1131486
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1131486