Imaging and Methotrexate Response Monitoring of Systemic Inflammation in Arthritic Rats Employing the Macrophage PET Tracer [18F]Fluoro-PEG-Folate
المؤلفون المشاركون
Windhorst, Albert D.
Chandrupatla, Durga M. S. H.
Jansen, Gerrit
van der Laken, Conny J.
Molthoff, Carla F. M.
Mantel, Elise
Low, Philip S.
Matsuyama, Takami
Musters, René P.
Lammertsma, Adriaan Anthonius
المصدر
Contrast Media & Molecular Imaging
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-02-21
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Background.
In rheumatoid arthritis, articular inflammation is a hallmark of disease, while the involvement of extra-articular tissues is less well defined.
Here, we examined the feasibility of PET imaging with the macrophage tracer [18F]fluoro-PEG-folate, targeting folate receptor β (FRβ), to monitor systemic inflammatory disease in liver and spleen of arthritic rats before and after methotrexate (MTX) treatment.
Methods.
[18F]Fluoro-PEG-folate PET scans (60 min) were acquired in saline- and MTX-treated (1 mg/kg, 4x) arthritic rats, followed by tissue resection and radiotracer distribution analysis.
Liver and spleen tissues were stained for ED1/ED2-macrophage markers and FRβ expression.
Results.
[18F]Fluoro-PEG-folate PET and ex vivo tissue distribution studies revealed a significant (p<0.01) 2-fold lower tracer uptake in both liver and spleen of MTX-treated arthritic rats.
Consistently, ED1- and ED2-positive macrophages were significantly (p<0.01) decreased in liver (4-fold) and spleen (3-fold) of MTX-treated compared with saline-treated rats.
Additionally, FRβ-positive macrophages were also significantly reduced in liver (5-fold, p<0.005) and spleen (3-fold, p<0.01) of MTX- versus saline-treated rats.
Conclusions.
MTX treatment reduced activated macrophages in liver and spleen, as markers for systemic inflammation in these organs.
Macrophage PET imaging with [18F]fluoro-PEG-folate holds promise for detection of systemic inflammation in RA as well as therapy (MTX) response monitoring.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chandrupatla, Durga M. S. H.& Jansen, Gerrit& Mantel, Elise& Low, Philip S.& Matsuyama, Takami& Musters, René P.…[et al.]. 2018. Imaging and Methotrexate Response Monitoring of Systemic Inflammation in Arthritic Rats Employing the Macrophage PET Tracer [18F]Fluoro-PEG-Folate. Contrast Media & Molecular Imaging،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1131557
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chandrupatla, Durga M. S. H.…[et al.]. Imaging and Methotrexate Response Monitoring of Systemic Inflammation in Arthritic Rats Employing the Macrophage PET Tracer [18F]Fluoro-PEG-Folate. Contrast Media & Molecular Imaging No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1131557
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chandrupatla, Durga M. S. H.& Jansen, Gerrit& Mantel, Elise& Low, Philip S.& Matsuyama, Takami& Musters, René P.…[et al.]. Imaging and Methotrexate Response Monitoring of Systemic Inflammation in Arthritic Rats Employing the Macrophage PET Tracer [18F]Fluoro-PEG-Folate. Contrast Media & Molecular Imaging. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1131557
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1131557
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر