Sorafenib-Loaded Long-Circulating Nanoliposomes for Liver Cancer Therapy
المؤلفون المشاركون
Ye, Haiwei
Zhou, Liping
Jin, Haili
Chen, Yunhua
Cheng, Die
Jiang, Ying
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-05-07
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
A type of sorafenib- (SOR-) loaded long-circulating nanoliposome was constructed, and the targeting performance and antitumor effects of the prepared liposome were evaluated in the present study.
Polyethylene glycol- (PEG-) modified long-circulating nanoliposomes (LC-NPs) were designed and prepared using reverse evaporation, and the LC-NPs were used for delivering sorafenib (LC-PEG-SOR-NPs).
Then, the anti-VEGFR antibody as a targeting moiety was chemically coupled with LC-PEG-SOR-NPs to form liver cancer-targeted nanoliposomes (anti-VEGFR-LC-PEG-SOR-NPs).
The drug entrapment and loading efficiency were measured.
And the cancer-targeting performance and therapeutic efficiency were evaluated both in vitro and in vivo.
The anti-VEGFR-LC-PEG-SOR-NPs with an average of 119.8±4.2 nm showed a uniform spherical structure.
The drug entrapment and loading efficiency were 92.5% and 18.5%, respectively.
The killing efficiency of anti-VEGFR-LC-PEG-SOR-NPs was up to 18% after incubating with liver cancer cells for 72 h.
Furthermore, the anti-VEGFR-LC-PEG-SOR-NPs could actively target at the tumor region and could efficiently inhibit tumor growth with negligible side effects.
This newly designed nanoliposomes had desirable dispersibility, high drug entrapment efficiency, tumor targeting and therapeutic efficiency, and good safety.
As a biocompatible nanocomposite, it was promising to become a novel and useful tumor-targeting nanodrug for liver cancer therapy.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ye, Haiwei& Zhou, Liping& Jin, Haili& Chen, Yunhua& Cheng, Die& Jiang, Ying. 2020. Sorafenib-Loaded Long-Circulating Nanoliposomes for Liver Cancer Therapy. BioMed Research International،Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1131576
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ye, Haiwei…[et al.]. Sorafenib-Loaded Long-Circulating Nanoliposomes for Liver Cancer Therapy. BioMed Research International No. 2020 (2020), pp.1-12.
https://search.emarefa.net/detail/BIM-1131576
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ye, Haiwei& Zhou, Liping& Jin, Haili& Chen, Yunhua& Cheng, Die& Jiang, Ying. Sorafenib-Loaded Long-Circulating Nanoliposomes for Liver Cancer Therapy. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1131576
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1131576
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر