Sorafenib-Loaded Long-Circulating Nanoliposomes for Liver Cancer Therapy
Joint Authors
Ye, Haiwei
Zhou, Liping
Jin, Haili
Chen, Yunhua
Cheng, Die
Jiang, Ying
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-05-07
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
A type of sorafenib- (SOR-) loaded long-circulating nanoliposome was constructed, and the targeting performance and antitumor effects of the prepared liposome were evaluated in the present study.
Polyethylene glycol- (PEG-) modified long-circulating nanoliposomes (LC-NPs) were designed and prepared using reverse evaporation, and the LC-NPs were used for delivering sorafenib (LC-PEG-SOR-NPs).
Then, the anti-VEGFR antibody as a targeting moiety was chemically coupled with LC-PEG-SOR-NPs to form liver cancer-targeted nanoliposomes (anti-VEGFR-LC-PEG-SOR-NPs).
The drug entrapment and loading efficiency were measured.
And the cancer-targeting performance and therapeutic efficiency were evaluated both in vitro and in vivo.
The anti-VEGFR-LC-PEG-SOR-NPs with an average of 119.8±4.2 nm showed a uniform spherical structure.
The drug entrapment and loading efficiency were 92.5% and 18.5%, respectively.
The killing efficiency of anti-VEGFR-LC-PEG-SOR-NPs was up to 18% after incubating with liver cancer cells for 72 h.
Furthermore, the anti-VEGFR-LC-PEG-SOR-NPs could actively target at the tumor region and could efficiently inhibit tumor growth with negligible side effects.
This newly designed nanoliposomes had desirable dispersibility, high drug entrapment efficiency, tumor targeting and therapeutic efficiency, and good safety.
As a biocompatible nanocomposite, it was promising to become a novel and useful tumor-targeting nanodrug for liver cancer therapy.
American Psychological Association (APA)
Ye, Haiwei& Zhou, Liping& Jin, Haili& Chen, Yunhua& Cheng, Die& Jiang, Ying. 2020. Sorafenib-Loaded Long-Circulating Nanoliposomes for Liver Cancer Therapy. BioMed Research International،Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1131576
Modern Language Association (MLA)
Ye, Haiwei…[et al.]. Sorafenib-Loaded Long-Circulating Nanoliposomes for Liver Cancer Therapy. BioMed Research International No. 2020 (2020), pp.1-12.
https://search.emarefa.net/detail/BIM-1131576
American Medical Association (AMA)
Ye, Haiwei& Zhou, Liping& Jin, Haili& Chen, Yunhua& Cheng, Die& Jiang, Ying. Sorafenib-Loaded Long-Circulating Nanoliposomes for Liver Cancer Therapy. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1131576
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1131576