Early Imaging Biomarker of Myocardial Glucose Adaptations in High-Fat-Diet-Induced Insulin Resistance Model by Using 18F-FDG PET and [U-13C]glucose Nuclear Magnetic Resonance Tracer
المؤلفون المشاركون
Chang, Shang-Hung
Chiu, Shao-Chieh
Lin, Gigin
Chung, Yi-Hsiu
Lu, Kuan-Ying
Lo, Chi-Jen
Hung, Li-Man
Huang, Jiung-Pang
Cheng, Mei-Ling
Wang, Chao-Hung
Tsai, Cheng-Kun
Lin, Yu-Chun
المصدر
Contrast Media & Molecular Imaging
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-07-12
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Background.
High-fat diet (HFD) induces systemic insulin resistance leading to myocardial dysfunction.
We aim to characterize the early adaptations of myocardial glucose utility to HFD-induced insulin resistance.
Methods.
Male Sprague–Dawley rats were assigned into two groups, fed a regular chow diet or HFD ad libitum for 10 weeks.
We used in vivo imaging of cardiac magnetic resonance (CMR), 18F-FDG PET, and ex vivo nuclear magnetic resonance (NMR) metabolomic analysis for the carbon-13-labeled glucose ([U-13C]Glc) perfused myocardium.
Results.
As compared with controls, HFD rats had a higher ejection fraction and a smaller left ventricular end-systolic volume (P<0.05), with SUVmax of myocardium on 18F-FDG PET significantly increased in 4 weeks (P<0.005).
The [U-13C]Glc probed the increased glucose uptake being metabolized into pyruvate and acetyl-CoA, undergoing oxidative phosphorylation via the tricarboxylic acid (TCA) cycle, and then synthesized into glutamic acid and glutamine, associated with overexpressed LC3B (P<0.05).
Conclusions.
HFD-induced IR associated with increased glucose utility undergoing oxidative phosphorylation via the TCA cycle in the myocardium is supported by overexpression of glucose transporter, acetyl-CoA synthase.
Noninvasive imaging biomarker has potentials in detecting the metabolic perturbations prior to the decline of the left ventricular function.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chung, Yi-Hsiu& Lu, Kuan-Ying& Chiu, Shao-Chieh& Lo, Chi-Jen& Hung, Li-Man& Huang, Jiung-Pang…[et al.]. 2018. Early Imaging Biomarker of Myocardial Glucose Adaptations in High-Fat-Diet-Induced Insulin Resistance Model by Using 18F-FDG PET and [U-13C]glucose Nuclear Magnetic Resonance Tracer. Contrast Media & Molecular Imaging،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1131605
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chung, Yi-Hsiu…[et al.]. Early Imaging Biomarker of Myocardial Glucose Adaptations in High-Fat-Diet-Induced Insulin Resistance Model by Using 18F-FDG PET and [U-13C]glucose Nuclear Magnetic Resonance Tracer. Contrast Media & Molecular Imaging No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1131605
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chung, Yi-Hsiu& Lu, Kuan-Ying& Chiu, Shao-Chieh& Lo, Chi-Jen& Hung, Li-Man& Huang, Jiung-Pang…[et al.]. Early Imaging Biomarker of Myocardial Glucose Adaptations in High-Fat-Diet-Induced Insulin Resistance Model by Using 18F-FDG PET and [U-13C]glucose Nuclear Magnetic Resonance Tracer. Contrast Media & Molecular Imaging. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1131605
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1131605
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر