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Early Imaging Biomarker of Myocardial Glucose Adaptations in High-Fat-Diet-Induced Insulin Resistance Model by Using 18F-FDG PET and [U-13C]glucose Nuclear Magnetic Resonance Tracer
Joint Authors
Chang, Shang-Hung
Chiu, Shao-Chieh
Lin, Gigin
Chung, Yi-Hsiu
Lu, Kuan-Ying
Lo, Chi-Jen
Hung, Li-Man
Huang, Jiung-Pang
Cheng, Mei-Ling
Wang, Chao-Hung
Tsai, Cheng-Kun
Lin, Yu-Chun
Source
Contrast Media & Molecular Imaging
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-07-12
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Background.
High-fat diet (HFD) induces systemic insulin resistance leading to myocardial dysfunction.
We aim to characterize the early adaptations of myocardial glucose utility to HFD-induced insulin resistance.
Methods.
Male Sprague–Dawley rats were assigned into two groups, fed a regular chow diet or HFD ad libitum for 10 weeks.
We used in vivo imaging of cardiac magnetic resonance (CMR), 18F-FDG PET, and ex vivo nuclear magnetic resonance (NMR) metabolomic analysis for the carbon-13-labeled glucose ([U-13C]Glc) perfused myocardium.
Results.
As compared with controls, HFD rats had a higher ejection fraction and a smaller left ventricular end-systolic volume (P<0.05), with SUVmax of myocardium on 18F-FDG PET significantly increased in 4 weeks (P<0.005).
The [U-13C]Glc probed the increased glucose uptake being metabolized into pyruvate and acetyl-CoA, undergoing oxidative phosphorylation via the tricarboxylic acid (TCA) cycle, and then synthesized into glutamic acid and glutamine, associated with overexpressed LC3B (P<0.05).
Conclusions.
HFD-induced IR associated with increased glucose utility undergoing oxidative phosphorylation via the TCA cycle in the myocardium is supported by overexpression of glucose transporter, acetyl-CoA synthase.
Noninvasive imaging biomarker has potentials in detecting the metabolic perturbations prior to the decline of the left ventricular function.
American Psychological Association (APA)
Chung, Yi-Hsiu& Lu, Kuan-Ying& Chiu, Shao-Chieh& Lo, Chi-Jen& Hung, Li-Man& Huang, Jiung-Pang…[et al.]. 2018. Early Imaging Biomarker of Myocardial Glucose Adaptations in High-Fat-Diet-Induced Insulin Resistance Model by Using 18F-FDG PET and [U-13C]glucose Nuclear Magnetic Resonance Tracer. Contrast Media & Molecular Imaging،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1131605
Modern Language Association (MLA)
Chung, Yi-Hsiu…[et al.]. Early Imaging Biomarker of Myocardial Glucose Adaptations in High-Fat-Diet-Induced Insulin Resistance Model by Using 18F-FDG PET and [U-13C]glucose Nuclear Magnetic Resonance Tracer. Contrast Media & Molecular Imaging No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1131605
American Medical Association (AMA)
Chung, Yi-Hsiu& Lu, Kuan-Ying& Chiu, Shao-Chieh& Lo, Chi-Jen& Hung, Li-Man& Huang, Jiung-Pang…[et al.]. Early Imaging Biomarker of Myocardial Glucose Adaptations in High-Fat-Diet-Induced Insulin Resistance Model by Using 18F-FDG PET and [U-13C]glucose Nuclear Magnetic Resonance Tracer. Contrast Media & Molecular Imaging. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1131605
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1131605