Amyloid-Beta Radiotracer [18F]BF-227 Does Not Bind to Cytoplasmic Glial Inclusions of Postmortem Multiple System Atrophy Brain Tissue
المؤلفون المشاركون
Zimmer, Luc
Billard, Thierry
Chauveau, Fabien
Verdurand, Mathieu
Levigoureux, Elise
Lancelot, Sophie
Zeinyeh, Waël
Quadrio, Isabelle
Perret-Liaudet, Armand
المصدر
Contrast Media & Molecular Imaging
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-02-06
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
The accumulation of aggregated alpha-synuclein (α-syn) in multiple brain regions is a neuropathological hallmark of synucleinopathies.
Multiple system atrophy (MSA) is a synucleinopathy characterized by the predominant cerebral accumulation of aggregated α-syn as cytoplasmic glial inclusions (CGI).
A premortem diagnosis tool would improve early diagnosis and help monitoring disease progression and therapeutic efficacy.
One Positron Emission Tomography (PET) study suggested [11C]BF-227 as a promising radiotracer for monitoring intracellular α-syn deposition in MSA patients.
We sought to confirm the binding of this radiotracer to α-syn using state-of-the-art autoradiography.
Medulla sections were obtained from 9 MSA patients and 9 controls (London Neurodegenerative Diseases Brain Bank).
[18F]BF-227, chemically identical to [11C]BF-227, was used at nanomolar concentrations to perform in vitro autoradiography assays.
Autoradiograms were superimposed on fluorescent staining from the conformational anti-α-syn antibody 5G4 and quantified after immunofluorescence-driven definition of regions of interest.
Autoradiography showed no specific signals in MSA patients in comparison to controls despite widespread pathology detected by immunofluorescence.
Autoradiography does not support a significant binding of [18F]BF-227 to CGI at concentrations typically achieved in PET experiments.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Verdurand, Mathieu& Levigoureux, Elise& Lancelot, Sophie& Zeinyeh, Waël& Billard, Thierry& Quadrio, Isabelle…[et al.]. 2018. Amyloid-Beta Radiotracer [18F]BF-227 Does Not Bind to Cytoplasmic Glial Inclusions of Postmortem Multiple System Atrophy Brain Tissue. Contrast Media & Molecular Imaging،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1131636
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Verdurand, Mathieu…[et al.]. Amyloid-Beta Radiotracer [18F]BF-227 Does Not Bind to Cytoplasmic Glial Inclusions of Postmortem Multiple System Atrophy Brain Tissue. Contrast Media & Molecular Imaging No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1131636
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Verdurand, Mathieu& Levigoureux, Elise& Lancelot, Sophie& Zeinyeh, Waël& Billard, Thierry& Quadrio, Isabelle…[et al.]. Amyloid-Beta Radiotracer [18F]BF-227 Does Not Bind to Cytoplasmic Glial Inclusions of Postmortem Multiple System Atrophy Brain Tissue. Contrast Media & Molecular Imaging. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1131636
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1131636
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر