Prognostic Value of Circular RNA ciRS-7 in Various Cancers: A PRISMA-Compliant Meta-Analysis
المؤلفون المشاركون
Tian, Guangwei
Li, Guang
Guan, Lin
Wang, Zihui
Li, Nan
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-01-23
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Background.
Circular RNAs (circRNAs) have been shown to be involved in tumorigenesis.
As a member of circRNAs, ciRS-7 is thought to be a negative prognostic indicator in multiple types of cancer.
The present study aimed to comprehensively explore the value of ciRS-7 in tumor malignancy.
Materials and Methods.
A systematic review of PubMed, Web of Science, and the Cochrane library was carried out to examine the related studies.
The pooled odds ratios (ORs) and hazard ratios (HRs) with 95% confidence intervals (95% CIs) were calculated from the available publications by STATA 12.0.
Subgroup analysis, publication bias, sensitivity analysis, and meta-regression were conducted.
Results.
This meta-analysis included 1,714 patients from 13 cohorts.
The results suggested that high ciRS-7 expression was significantly associated with overall survival (OS) (HR = 2.17, 95% CI = 1.50–3.15, P<0.001) in various cancers.
Stratified analyses indicated that elevated levels of ciRS-7 appeared to be a powerful prognostic biomarker for patients with non-small-cell lung cancer (NSCLC) (HR: 2.50, 95% CI: 1.07–6.07, P=0.035), colorectal cancer (CRC) (HR: 1.95, 95% CI: 1.34–2.84, P<0.001), and gastric cancer (GC) (HR: 2.32, 95% CI: 1.48–3.64, P<0.001).
A similar effect was also observed in subgroup of sample size, analysis method, and cutoff value, except for ethnicity.
The increased ciRS-7 expression was associated with a higher tumor stage (OR = 2.30, 95% CI: 1.69–3.13, P<0.001).
Conclusions.
High expression of ciRS-7 has a significant correlation with the high stage in various cancers, and ciRS-7 is intimately associated with an adverse OS in numerous cancers.
Thus, ciRS-7 may act as a potential biomarker for the development of malignancies.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Tian, Guangwei& Li, Guang& Guan, Lin& Wang, Zihui& Li, Nan. 2020. Prognostic Value of Circular RNA ciRS-7 in Various Cancers: A PRISMA-Compliant Meta-Analysis. BioMed Research International،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1131682
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Tian, Guangwei…[et al.]. Prognostic Value of Circular RNA ciRS-7 in Various Cancers: A PRISMA-Compliant Meta-Analysis. BioMed Research International No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1131682
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Tian, Guangwei& Li, Guang& Guan, Lin& Wang, Zihui& Li, Nan. Prognostic Value of Circular RNA ciRS-7 in Various Cancers: A PRISMA-Compliant Meta-Analysis. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1131682
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1131682
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر