![](/images/graphics-bg.png)
Prognostic Value of Circular RNA ciRS-7 in Various Cancers: A PRISMA-Compliant Meta-Analysis
Joint Authors
Tian, Guangwei
Li, Guang
Guan, Lin
Wang, Zihui
Li, Nan
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-01-23
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Background.
Circular RNAs (circRNAs) have been shown to be involved in tumorigenesis.
As a member of circRNAs, ciRS-7 is thought to be a negative prognostic indicator in multiple types of cancer.
The present study aimed to comprehensively explore the value of ciRS-7 in tumor malignancy.
Materials and Methods.
A systematic review of PubMed, Web of Science, and the Cochrane library was carried out to examine the related studies.
The pooled odds ratios (ORs) and hazard ratios (HRs) with 95% confidence intervals (95% CIs) were calculated from the available publications by STATA 12.0.
Subgroup analysis, publication bias, sensitivity analysis, and meta-regression were conducted.
Results.
This meta-analysis included 1,714 patients from 13 cohorts.
The results suggested that high ciRS-7 expression was significantly associated with overall survival (OS) (HR = 2.17, 95% CI = 1.50–3.15, P<0.001) in various cancers.
Stratified analyses indicated that elevated levels of ciRS-7 appeared to be a powerful prognostic biomarker for patients with non-small-cell lung cancer (NSCLC) (HR: 2.50, 95% CI: 1.07–6.07, P=0.035), colorectal cancer (CRC) (HR: 1.95, 95% CI: 1.34–2.84, P<0.001), and gastric cancer (GC) (HR: 2.32, 95% CI: 1.48–3.64, P<0.001).
A similar effect was also observed in subgroup of sample size, analysis method, and cutoff value, except for ethnicity.
The increased ciRS-7 expression was associated with a higher tumor stage (OR = 2.30, 95% CI: 1.69–3.13, P<0.001).
Conclusions.
High expression of ciRS-7 has a significant correlation with the high stage in various cancers, and ciRS-7 is intimately associated with an adverse OS in numerous cancers.
Thus, ciRS-7 may act as a potential biomarker for the development of malignancies.
American Psychological Association (APA)
Tian, Guangwei& Li, Guang& Guan, Lin& Wang, Zihui& Li, Nan. 2020. Prognostic Value of Circular RNA ciRS-7 in Various Cancers: A PRISMA-Compliant Meta-Analysis. BioMed Research International،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1131682
Modern Language Association (MLA)
Tian, Guangwei…[et al.]. Prognostic Value of Circular RNA ciRS-7 in Various Cancers: A PRISMA-Compliant Meta-Analysis. BioMed Research International No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1131682
American Medical Association (AMA)
Tian, Guangwei& Li, Guang& Guan, Lin& Wang, Zihui& Li, Nan. Prognostic Value of Circular RNA ciRS-7 in Various Cancers: A PRISMA-Compliant Meta-Analysis. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1131682
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1131682