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Jiao-Tai-Wan Ameliorates Depressive-Like Behavior through the A1R Pathway in Ovariectomized Mice after Unpredictable Chronic Stress
المؤلفون المشاركون
Xiang, Lina
Hu, Qianqian
Zhu, Jiahui
Ye, Ren
Yuan, Zhengzhong
Feng, Yuan
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-09-18
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Objective.
This study was aimed at observing the effect Jiao-Tai-Wan in menopausal depression.
Methods.
In this paper, we used ovariectomized mice subjected to chronic unpredictable stress as a menopausal depression model.
After the chronic stress, mice were administrated with JTW (3.3 and 6.6mg/kg) and imipramine (10 mg/kg) for 14 days.
On the 14th day, mice were subjected to the behavior test like the forced swim test, tail suspension test, and locomotor activity or were sacrificed to assess the protein changes in different brain regions.
Results.
The administration of JTW at doses of 3.3 and 6.6mg/kg (p.o.) significantly shortened the duration of immobility in forced swim and tail suspension tests.
There was no obvious difference in locomotor activity among all the groups.
The western blot analysis data indicated that treatment with JTW (3.3 and 6.6 mg/kg, p.o.) prominently increased the A1R protein and the downstream protein ERK1/2 levels in the prefrontal cortex and hippocampus.
However, the administration of JTW did not influence c-Fos protein in either the prefrontal cortex or hippocampus.
Conclusion.
Our findings suggest that JTW plays a vital role in ameliorating menopausal depression symptoms in the A1R-ERK1/2 pathway in the prefrontal cortex and hippocampus.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Xiang, Lina& Feng, Yuan& Hu, Qianqian& Zhu, Jiahui& Ye, Ren& Yuan, Zhengzhong. 2020. Jiao-Tai-Wan Ameliorates Depressive-Like Behavior through the A1R Pathway in Ovariectomized Mice after Unpredictable Chronic Stress. BioMed Research International،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1131694
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Xiang, Lina…[et al.]. Jiao-Tai-Wan Ameliorates Depressive-Like Behavior through the A1R Pathway in Ovariectomized Mice after Unpredictable Chronic Stress. BioMed Research International No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1131694
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Xiang, Lina& Feng, Yuan& Hu, Qianqian& Zhu, Jiahui& Ye, Ren& Yuan, Zhengzhong. Jiao-Tai-Wan Ameliorates Depressive-Like Behavior through the A1R Pathway in Ovariectomized Mice after Unpredictable Chronic Stress. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1131694
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1131694
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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