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Jiao-Tai-Wan Ameliorates Depressive-Like Behavior through the A1R Pathway in Ovariectomized Mice after Unpredictable Chronic Stress
Joint Authors
Xiang, Lina
Hu, Qianqian
Zhu, Jiahui
Ye, Ren
Yuan, Zhengzhong
Feng, Yuan
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-09-18
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Objective.
This study was aimed at observing the effect Jiao-Tai-Wan in menopausal depression.
Methods.
In this paper, we used ovariectomized mice subjected to chronic unpredictable stress as a menopausal depression model.
After the chronic stress, mice were administrated with JTW (3.3 and 6.6mg/kg) and imipramine (10 mg/kg) for 14 days.
On the 14th day, mice were subjected to the behavior test like the forced swim test, tail suspension test, and locomotor activity or were sacrificed to assess the protein changes in different brain regions.
Results.
The administration of JTW at doses of 3.3 and 6.6mg/kg (p.o.) significantly shortened the duration of immobility in forced swim and tail suspension tests.
There was no obvious difference in locomotor activity among all the groups.
The western blot analysis data indicated that treatment with JTW (3.3 and 6.6 mg/kg, p.o.) prominently increased the A1R protein and the downstream protein ERK1/2 levels in the prefrontal cortex and hippocampus.
However, the administration of JTW did not influence c-Fos protein in either the prefrontal cortex or hippocampus.
Conclusion.
Our findings suggest that JTW plays a vital role in ameliorating menopausal depression symptoms in the A1R-ERK1/2 pathway in the prefrontal cortex and hippocampus.
American Psychological Association (APA)
Xiang, Lina& Feng, Yuan& Hu, Qianqian& Zhu, Jiahui& Ye, Ren& Yuan, Zhengzhong. 2020. Jiao-Tai-Wan Ameliorates Depressive-Like Behavior through the A1R Pathway in Ovariectomized Mice after Unpredictable Chronic Stress. BioMed Research International،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1131694
Modern Language Association (MLA)
Xiang, Lina…[et al.]. Jiao-Tai-Wan Ameliorates Depressive-Like Behavior through the A1R Pathway in Ovariectomized Mice after Unpredictable Chronic Stress. BioMed Research International No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1131694
American Medical Association (AMA)
Xiang, Lina& Feng, Yuan& Hu, Qianqian& Zhu, Jiahui& Ye, Ren& Yuan, Zhengzhong. Jiao-Tai-Wan Ameliorates Depressive-Like Behavior through the A1R Pathway in Ovariectomized Mice after Unpredictable Chronic Stress. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1131694
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1131694