Mechanism of YuPingFeng in the Treatment of COPD Based on Network Pharmacology
المؤلفون المشاركون
Yin, Yunhong
Liu, Jianyu
Zhang, Mengyu
Li, Rui
Liu, Xiao
Yang, Yican
Qu, Yi-Qing
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-05-28
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
YuPingFeng (YPF) granules are a classic herbal formula extensively used in clinical practice in China for the treatment of COPD.
However, the pathological mechanisms of YPF in COPD remain undefined.
In the present research, a network pharmacology-based strategy was implemented to elucidate the underlying multicomponent, multitarget, and multipathway modes of action of YPF against COPD.
First, we identified putative YPF targets based on TCMSP databases and constructed a network containing interactions between putative YPF targets and known therapeutic targets of COPD.
Next, two topological parameters, “degree” and “closeness,” were calculated to identify target genes in the network.
The major hubs were imported to the MetaCore database for pathway enrichment analysis.
In total, 23 YPF active ingredients and 83 target genes associated with COPD were identified.
Through protein interaction network analysis, 26 genes were identified as major hubs due to their topological importance.
GO and KEGG enrichment analysis results revealed YPF to be mainly associated with the response to glucocorticoids and steroid hormones, with apoptotic and HIF-1 signalling pathways being dominant and correlative pathways.
The promising utility of YPF in the treatment of COPD has been demonstrated by a network pharmacology approach.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Yin, Yunhong& Liu, Jianyu& Zhang, Mengyu& Li, Rui& Liu, Xiao& Yang, Yican…[et al.]. 2020. Mechanism of YuPingFeng in the Treatment of COPD Based on Network Pharmacology. BioMed Research International،Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1131772
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Yin, Yunhong…[et al.]. Mechanism of YuPingFeng in the Treatment of COPD Based on Network Pharmacology. BioMed Research International No. 2020 (2020), pp.1-13.
https://search.emarefa.net/detail/BIM-1131772
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Yin, Yunhong& Liu, Jianyu& Zhang, Mengyu& Li, Rui& Liu, Xiao& Yang, Yican…[et al.]. Mechanism of YuPingFeng in the Treatment of COPD Based on Network Pharmacology. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1131772
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1131772
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر