Mechanism of YuPingFeng in the Treatment of COPD Based on Network Pharmacology
Joint Authors
Yin, Yunhong
Liu, Jianyu
Zhang, Mengyu
Li, Rui
Liu, Xiao
Yang, Yican
Qu, Yi-Qing
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-05-28
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
YuPingFeng (YPF) granules are a classic herbal formula extensively used in clinical practice in China for the treatment of COPD.
However, the pathological mechanisms of YPF in COPD remain undefined.
In the present research, a network pharmacology-based strategy was implemented to elucidate the underlying multicomponent, multitarget, and multipathway modes of action of YPF against COPD.
First, we identified putative YPF targets based on TCMSP databases and constructed a network containing interactions between putative YPF targets and known therapeutic targets of COPD.
Next, two topological parameters, “degree” and “closeness,” were calculated to identify target genes in the network.
The major hubs were imported to the MetaCore database for pathway enrichment analysis.
In total, 23 YPF active ingredients and 83 target genes associated with COPD were identified.
Through protein interaction network analysis, 26 genes were identified as major hubs due to their topological importance.
GO and KEGG enrichment analysis results revealed YPF to be mainly associated with the response to glucocorticoids and steroid hormones, with apoptotic and HIF-1 signalling pathways being dominant and correlative pathways.
The promising utility of YPF in the treatment of COPD has been demonstrated by a network pharmacology approach.
American Psychological Association (APA)
Yin, Yunhong& Liu, Jianyu& Zhang, Mengyu& Li, Rui& Liu, Xiao& Yang, Yican…[et al.]. 2020. Mechanism of YuPingFeng in the Treatment of COPD Based on Network Pharmacology. BioMed Research International،Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1131772
Modern Language Association (MLA)
Yin, Yunhong…[et al.]. Mechanism of YuPingFeng in the Treatment of COPD Based on Network Pharmacology. BioMed Research International No. 2020 (2020), pp.1-13.
https://search.emarefa.net/detail/BIM-1131772
American Medical Association (AMA)
Yin, Yunhong& Liu, Jianyu& Zhang, Mengyu& Li, Rui& Liu, Xiao& Yang, Yican…[et al.]. Mechanism of YuPingFeng in the Treatment of COPD Based on Network Pharmacology. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1131772
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1131772