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Direct-Current Electric Field Distribution in the Brain for Tumor Treating Field Applications: A Simulation Study
المؤلف
المصدر
Computational and Mathematical Methods in Medicine
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-02-22
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Tumor Treating Fields (TTFields) in combination with chemotherapy and/or radiotherapy have been clinically reported to provide prolonged overall survival in glioblastoma patients.
Alternating electric fields with frequencies of 100~300 kHz and magnitudes of 1~3 V/cm are shown to suppress the growth of cancer cells via interactions with polar molecules within dividing cells.
Since it is difficult to directly measure the electric fields inside the brain, simulation models of the human head provide a useful tool for predicting the electric field distribution.
In the present study, a three-dimensional finite element head model consisting of the scalp, the skull, the dura, the cerebrospinal fluid, and the brain was built to study the electric field distribution under various applied potentials and electrode configurations.
For simplicity, a direct-current electric field was used in the simulation.
The total power dissipation and temperature elevation due to Joule heating in different head tissues were also evaluated.
Based on the results, some guidelines are obtained in designing the electrode configuration for personalized glioblastoma electrotherapy.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Sun, Yung-Shin. 2018. Direct-Current Electric Field Distribution in the Brain for Tumor Treating Field Applications: A Simulation Study. Computational and Mathematical Methods in Medicine،Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1131959
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Sun, Yung-Shin. Direct-Current Electric Field Distribution in the Brain for Tumor Treating Field Applications: A Simulation Study. Computational and Mathematical Methods in Medicine No. 2018 (2018), pp.1-13.
https://search.emarefa.net/detail/BIM-1131959
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Sun, Yung-Shin. Direct-Current Electric Field Distribution in the Brain for Tumor Treating Field Applications: A Simulation Study. Computational and Mathematical Methods in Medicine. 2018. Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1131959
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1131959
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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