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Direct-Current Electric Field Distribution in the Brain for Tumor Treating Field Applications: A Simulation Study
Author
Source
Computational and Mathematical Methods in Medicine
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-02-22
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Tumor Treating Fields (TTFields) in combination with chemotherapy and/or radiotherapy have been clinically reported to provide prolonged overall survival in glioblastoma patients.
Alternating electric fields with frequencies of 100~300 kHz and magnitudes of 1~3 V/cm are shown to suppress the growth of cancer cells via interactions with polar molecules within dividing cells.
Since it is difficult to directly measure the electric fields inside the brain, simulation models of the human head provide a useful tool for predicting the electric field distribution.
In the present study, a three-dimensional finite element head model consisting of the scalp, the skull, the dura, the cerebrospinal fluid, and the brain was built to study the electric field distribution under various applied potentials and electrode configurations.
For simplicity, a direct-current electric field was used in the simulation.
The total power dissipation and temperature elevation due to Joule heating in different head tissues were also evaluated.
Based on the results, some guidelines are obtained in designing the electrode configuration for personalized glioblastoma electrotherapy.
American Psychological Association (APA)
Sun, Yung-Shin. 2018. Direct-Current Electric Field Distribution in the Brain for Tumor Treating Field Applications: A Simulation Study. Computational and Mathematical Methods in Medicine،Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1131959
Modern Language Association (MLA)
Sun, Yung-Shin. Direct-Current Electric Field Distribution in the Brain for Tumor Treating Field Applications: A Simulation Study. Computational and Mathematical Methods in Medicine No. 2018 (2018), pp.1-13.
https://search.emarefa.net/detail/BIM-1131959
American Medical Association (AMA)
Sun, Yung-Shin. Direct-Current Electric Field Distribution in the Brain for Tumor Treating Field Applications: A Simulation Study. Computational and Mathematical Methods in Medicine. 2018. Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1131959
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1131959