Explicit Theoretical Analysis of How the Rate of Exocytosis Depends on Local Control by Ca2+ Channels
المؤلفون المشاركون
Montefusco, Francesco
Pedersen, Morten Gram
المصدر
Computational and Mathematical Methods in Medicine
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-11-14
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Hormones and neurotransmitters are released from cells by calcium-regulated exocytosis, and local coupling between Ca2+ channels (CaVs) and secretory granules is a key factor determining the exocytosis rate.
Here, we devise a methodology based on Markov chain models that allows us to obtain analytic results for the expected rate.
First, we analyze the property of the secretory complex obtained by coupling a single granule with one CaV.
Then, we extend our results to a more general case where the granule is coupled with n CaVs.
We investigate how the exocytosis rate is affected by varying the location of granules and CaVs.
Moreover, we assume that the single granule can form complexes with inactivating or non-inactivating CaVs.
We find that increasing the number of CaVs coupled with the granule determines a much higher rise of the exocytosis rate that, in case of inactivating CaVs, is more pronounced when the granule is close to CaVs, while, surprisingly, in case of non-inactivating CaVs, the highest relative increase in rate is obtained when the granule is far from the CaVs.
Finally, we exploit the devised model to investigate the relation between exocytosis and calcium influx.
We find that the quantities are typically linearly related, as observed experimentally.
For the case of inactivating CaVs, our simulations show a change of the linear relation due to near-complete inactivation of CaVs.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Montefusco, Francesco& Pedersen, Morten Gram. 2018. Explicit Theoretical Analysis of How the Rate of Exocytosis Depends on Local Control by Ca2+ Channels. Computational and Mathematical Methods in Medicine،Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1132067
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Montefusco, Francesco& Pedersen, Morten Gram. Explicit Theoretical Analysis of How the Rate of Exocytosis Depends on Local Control by Ca2+ Channels. Computational and Mathematical Methods in Medicine No. 2018 (2018), pp.1-12.
https://search.emarefa.net/detail/BIM-1132067
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Montefusco, Francesco& Pedersen, Morten Gram. Explicit Theoretical Analysis of How the Rate of Exocytosis Depends on Local Control by Ca2+ Channels. Computational and Mathematical Methods in Medicine. 2018. Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1132067
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1132067
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر