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Explicit Theoretical Analysis of How the Rate of Exocytosis Depends on Local Control by Ca2+ Channels
Joint Authors
Montefusco, Francesco
Pedersen, Morten Gram
Source
Computational and Mathematical Methods in Medicine
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-11-14
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Hormones and neurotransmitters are released from cells by calcium-regulated exocytosis, and local coupling between Ca2+ channels (CaVs) and secretory granules is a key factor determining the exocytosis rate.
Here, we devise a methodology based on Markov chain models that allows us to obtain analytic results for the expected rate.
First, we analyze the property of the secretory complex obtained by coupling a single granule with one CaV.
Then, we extend our results to a more general case where the granule is coupled with n CaVs.
We investigate how the exocytosis rate is affected by varying the location of granules and CaVs.
Moreover, we assume that the single granule can form complexes with inactivating or non-inactivating CaVs.
We find that increasing the number of CaVs coupled with the granule determines a much higher rise of the exocytosis rate that, in case of inactivating CaVs, is more pronounced when the granule is close to CaVs, while, surprisingly, in case of non-inactivating CaVs, the highest relative increase in rate is obtained when the granule is far from the CaVs.
Finally, we exploit the devised model to investigate the relation between exocytosis and calcium influx.
We find that the quantities are typically linearly related, as observed experimentally.
For the case of inactivating CaVs, our simulations show a change of the linear relation due to near-complete inactivation of CaVs.
American Psychological Association (APA)
Montefusco, Francesco& Pedersen, Morten Gram. 2018. Explicit Theoretical Analysis of How the Rate of Exocytosis Depends on Local Control by Ca2+ Channels. Computational and Mathematical Methods in Medicine،Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1132067
Modern Language Association (MLA)
Montefusco, Francesco& Pedersen, Morten Gram. Explicit Theoretical Analysis of How the Rate of Exocytosis Depends on Local Control by Ca2+ Channels. Computational and Mathematical Methods in Medicine No. 2018 (2018), pp.1-12.
https://search.emarefa.net/detail/BIM-1132067
American Medical Association (AMA)
Montefusco, Francesco& Pedersen, Morten Gram. Explicit Theoretical Analysis of How the Rate of Exocytosis Depends on Local Control by Ca2+ Channels. Computational and Mathematical Methods in Medicine. 2018. Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1132067
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1132067