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The Significance of Circular RNA DDX17 in Prostate Cancer
المؤلفون المشاركون
Lin, Qi
Cai, Jian
Wang, Qin-Quan
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-16، 16ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-08-21
دولة النشر
مصر
عدد الصفحات
16
التخصصات الرئيسية
الملخص EN
Circular RNA DDX17 (circDDX17) has been demonstrated as a tumor suppressor in colorectal cancer.
However, mechanisms underlying circDDX17 effects in cases of prostate cancer (PCa) are not well understood.
Thus, herein, we determined measures of circDDX17 expression by use of the TCGA database.
Expression of circDDX17 in prostate cancer-afflicted tissue samples was determined by qRT-PCR.
Functionally, circDDX17 induced remarkable inhibition of cell colonizing ability, invasion, and epithelial-mesenchymal transition (EMT) progression in vitro.
Mechanistically, dual-luciferase reporter assays, RNA immunoprecipitation, and RNA pull-down experiments helped verify interactions between circDDX17 and miR-346.
Low expression of circDDX17 occurred in TCGA PCa samples.
Furthermore, circDDX17 expression was downregulated significantly in PCa.
These results suggested that circDDX17 suppressed PC cell mobility, proliferation, and invasion.
Mechanistic experiments indicated that circDDX17 might serve as a ceRNA of miR-346 to relieve repressive effects of miR-346 upon phospholysine phosphohistidine inorganic pyrophosphate phosphatase (LHPP).
LHPP expression itself was downregulated in TCGA PCa samples.
Overall, our findings indicated that the circDDX17/miR-346/LHPP pathway inhibited the progression of prostate cancer and that circDDX17 may be a new potential therapeutic or diagnostic target for treating and diagnosing prostate cancer.
As our study also demonstrated for the first time that LHPP might act as an anticancer gene in prostate cancer, the findings could have wide-ranging implications for the treatment of this affliction.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lin, Qi& Cai, Jian& Wang, Qin-Quan. 2020. The Significance of Circular RNA DDX17 in Prostate Cancer. BioMed Research International،Vol. 2020, no. 2020, pp.1-16.
https://search.emarefa.net/detail/BIM-1132112
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lin, Qi…[et al.]. The Significance of Circular RNA DDX17 in Prostate Cancer. BioMed Research International No. 2020 (2020), pp.1-16.
https://search.emarefa.net/detail/BIM-1132112
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lin, Qi& Cai, Jian& Wang, Qin-Quan. The Significance of Circular RNA DDX17 in Prostate Cancer. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-16.
https://search.emarefa.net/detail/BIM-1132112
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1132112
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
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