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The Significance of Circular RNA DDX17 in Prostate Cancer
Joint Authors
Lin, Qi
Cai, Jian
Wang, Qin-Quan
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-08-21
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
Circular RNA DDX17 (circDDX17) has been demonstrated as a tumor suppressor in colorectal cancer.
However, mechanisms underlying circDDX17 effects in cases of prostate cancer (PCa) are not well understood.
Thus, herein, we determined measures of circDDX17 expression by use of the TCGA database.
Expression of circDDX17 in prostate cancer-afflicted tissue samples was determined by qRT-PCR.
Functionally, circDDX17 induced remarkable inhibition of cell colonizing ability, invasion, and epithelial-mesenchymal transition (EMT) progression in vitro.
Mechanistically, dual-luciferase reporter assays, RNA immunoprecipitation, and RNA pull-down experiments helped verify interactions between circDDX17 and miR-346.
Low expression of circDDX17 occurred in TCGA PCa samples.
Furthermore, circDDX17 expression was downregulated significantly in PCa.
These results suggested that circDDX17 suppressed PC cell mobility, proliferation, and invasion.
Mechanistic experiments indicated that circDDX17 might serve as a ceRNA of miR-346 to relieve repressive effects of miR-346 upon phospholysine phosphohistidine inorganic pyrophosphate phosphatase (LHPP).
LHPP expression itself was downregulated in TCGA PCa samples.
Overall, our findings indicated that the circDDX17/miR-346/LHPP pathway inhibited the progression of prostate cancer and that circDDX17 may be a new potential therapeutic or diagnostic target for treating and diagnosing prostate cancer.
As our study also demonstrated for the first time that LHPP might act as an anticancer gene in prostate cancer, the findings could have wide-ranging implications for the treatment of this affliction.
American Psychological Association (APA)
Lin, Qi& Cai, Jian& Wang, Qin-Quan. 2020. The Significance of Circular RNA DDX17 in Prostate Cancer. BioMed Research International،Vol. 2020, no. 2020, pp.1-16.
https://search.emarefa.net/detail/BIM-1132112
Modern Language Association (MLA)
Lin, Qi…[et al.]. The Significance of Circular RNA DDX17 in Prostate Cancer. BioMed Research International No. 2020 (2020), pp.1-16.
https://search.emarefa.net/detail/BIM-1132112
American Medical Association (AMA)
Lin, Qi& Cai, Jian& Wang, Qin-Quan. The Significance of Circular RNA DDX17 in Prostate Cancer. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-16.
https://search.emarefa.net/detail/BIM-1132112
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1132112