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Influence of Different Dosage Forms on Pharmacokinetics of 6 Alkaloids in Raw Aconiti Kusnezoffii Radix (Caowu) and Chebulae Fructus- (Hezi-) Processed Caowu by UPLC-MSMS
المؤلفون المشاركون
Li, Feng
Liu, Kaiyang
Zhi, Meiru
Xu, Jinkai
Li, Weifei
Han, Xitao
Tang, Yanan
Liu, Ziqin
Du, Hong
Han, Shu
Wang, Hongyue
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-09-22
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Purpose.
To study the pharmacokinetics of the 6 alkaloids (aconitine, mesaconitine, hypaconitine, benzoylaconine, benzoylmesaconine, and benzoylhypaconine) in raw Aconiti Kusnezoffii Radix (Caowu) (RC) and Chebulae Fructus- (Hezi-) processed Caowu (HC) in the rats being, respectively, administrated with RC and HC in the dosage forms of powder and decoction and to demonstrate the mechanism of detoxification of HC.
Methods.
The rats were randomly divided into 4 groups and, respectively, given RC powder, HC powder, RC decoction, and HC decoction by intragastric administration.
The contents of the 6 alkaloids in the plasma of the rats were detected at different time points by the UPLC-MS/MS method, and DAS 3.2.7 software was used to calculate, compare, and analyze the detected pharmacokinetic parameters.
Results.
Compared with those of the RC powder, the values of AUC0‐t and Cmax of the HC powder were all reduced, whereas the values of t1/2z and Tmax were mostly increased.
Compared with those of the RC powder, the values of AUC0‐t, Cmax, and t1/2z of the RC decoction were decreased and the value of Tmax of the RC decoction was increased.
Compared with those of the RC decoction, the values of AUC0‐t, t1/2z, and Cmax of the diester diterpenoid alkaloids of the HC decoction were all increased.
However, there was no marked difference between the pharmacokinetic parameters of the HC powder and the HC decoction.
Conclusions.
A decrease in the level of absorption and in the rate of elimination of the alkaloids can be detected when HC is administrated in the dosage form of the powder, explaining that in traditional Mongolian medicine (TMM), the purpose of using HC in the dosage forms of pills and powder is for decreasing the toxicity and prolonging the efficacy duration of HC.
Decocting can greatly decrease the plasma concentration of the diester diterpenoid alkaloids in RC and increase their rate of elimination.
The influence of decocting on RC is greater than that on HC, explaining the rationality of the steaming and boiling methods for processing Caowu and the rationality of boiling Caowu for a longer time beforehand in preparing an herb decoction containing Caowu in TCM.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhi, Meiru& Liu, Kaiyang& Han, Shu& Xu, Jinkai& Li, Weifei& Li, Feng…[et al.]. 2020. Influence of Different Dosage Forms on Pharmacokinetics of 6 Alkaloids in Raw Aconiti Kusnezoffii Radix (Caowu) and Chebulae Fructus- (Hezi-) Processed Caowu by UPLC-MSMS. BioMed Research International،Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1132178
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhi, Meiru…[et al.]. Influence of Different Dosage Forms on Pharmacokinetics of 6 Alkaloids in Raw Aconiti Kusnezoffii Radix (Caowu) and Chebulae Fructus- (Hezi-) Processed Caowu by UPLC-MSMS. BioMed Research International No. 2020 (2020), pp.1-12.
https://search.emarefa.net/detail/BIM-1132178
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhi, Meiru& Liu, Kaiyang& Han, Shu& Xu, Jinkai& Li, Weifei& Li, Feng…[et al.]. Influence of Different Dosage Forms on Pharmacokinetics of 6 Alkaloids in Raw Aconiti Kusnezoffii Radix (Caowu) and Chebulae Fructus- (Hezi-) Processed Caowu by UPLC-MSMS. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1132178
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1132178
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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