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Influence of Different Dosage Forms on Pharmacokinetics of 6 Alkaloids in Raw Aconiti Kusnezoffii Radix (Caowu) and Chebulae Fructus- (Hezi-) Processed Caowu by UPLC-MSMS
Joint Authors
Li, Feng
Liu, Kaiyang
Zhi, Meiru
Xu, Jinkai
Li, Weifei
Han, Xitao
Tang, Yanan
Liu, Ziqin
Du, Hong
Han, Shu
Wang, Hongyue
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-09-22
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Purpose.
To study the pharmacokinetics of the 6 alkaloids (aconitine, mesaconitine, hypaconitine, benzoylaconine, benzoylmesaconine, and benzoylhypaconine) in raw Aconiti Kusnezoffii Radix (Caowu) (RC) and Chebulae Fructus- (Hezi-) processed Caowu (HC) in the rats being, respectively, administrated with RC and HC in the dosage forms of powder and decoction and to demonstrate the mechanism of detoxification of HC.
Methods.
The rats were randomly divided into 4 groups and, respectively, given RC powder, HC powder, RC decoction, and HC decoction by intragastric administration.
The contents of the 6 alkaloids in the plasma of the rats were detected at different time points by the UPLC-MS/MS method, and DAS 3.2.7 software was used to calculate, compare, and analyze the detected pharmacokinetic parameters.
Results.
Compared with those of the RC powder, the values of AUC0‐t and Cmax of the HC powder were all reduced, whereas the values of t1/2z and Tmax were mostly increased.
Compared with those of the RC powder, the values of AUC0‐t, Cmax, and t1/2z of the RC decoction were decreased and the value of Tmax of the RC decoction was increased.
Compared with those of the RC decoction, the values of AUC0‐t, t1/2z, and Cmax of the diester diterpenoid alkaloids of the HC decoction were all increased.
However, there was no marked difference between the pharmacokinetic parameters of the HC powder and the HC decoction.
Conclusions.
A decrease in the level of absorption and in the rate of elimination of the alkaloids can be detected when HC is administrated in the dosage form of the powder, explaining that in traditional Mongolian medicine (TMM), the purpose of using HC in the dosage forms of pills and powder is for decreasing the toxicity and prolonging the efficacy duration of HC.
Decocting can greatly decrease the plasma concentration of the diester diterpenoid alkaloids in RC and increase their rate of elimination.
The influence of decocting on RC is greater than that on HC, explaining the rationality of the steaming and boiling methods for processing Caowu and the rationality of boiling Caowu for a longer time beforehand in preparing an herb decoction containing Caowu in TCM.
American Psychological Association (APA)
Zhi, Meiru& Liu, Kaiyang& Han, Shu& Xu, Jinkai& Li, Weifei& Li, Feng…[et al.]. 2020. Influence of Different Dosage Forms on Pharmacokinetics of 6 Alkaloids in Raw Aconiti Kusnezoffii Radix (Caowu) and Chebulae Fructus- (Hezi-) Processed Caowu by UPLC-MSMS. BioMed Research International،Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1132178
Modern Language Association (MLA)
Zhi, Meiru…[et al.]. Influence of Different Dosage Forms on Pharmacokinetics of 6 Alkaloids in Raw Aconiti Kusnezoffii Radix (Caowu) and Chebulae Fructus- (Hezi-) Processed Caowu by UPLC-MSMS. BioMed Research International No. 2020 (2020), pp.1-12.
https://search.emarefa.net/detail/BIM-1132178
American Medical Association (AMA)
Zhi, Meiru& Liu, Kaiyang& Han, Shu& Xu, Jinkai& Li, Weifei& Li, Feng…[et al.]. Influence of Different Dosage Forms on Pharmacokinetics of 6 Alkaloids in Raw Aconiti Kusnezoffii Radix (Caowu) and Chebulae Fructus- (Hezi-) Processed Caowu by UPLC-MSMS. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1132178
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1132178