Association between ELABELA Serum Concentrations in First Trimester and Pregnancy-Induced Hypertension
المؤلفون المشاركون
Ma, Shujuan
Guo, Chuhao
Zhang, Jiayue
Long, Sisi
Tan, Hongzhuan
You, Yiping
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-09-28
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
ELABELA (ELA) is considered to be implicated in the pathophysiology of preeclampsia (PE), since ELA-deficient mice exhibited PE-like symptoms and infusion of exogenous ELA normalized the gestational hypertension (GH) and proteinuria.
However, no evidence show that circulating ELA is deficient in early placental development among women who destined to develop GH/PE.
This nested case-control study was conducted to investigate the association between serum ELA concentration in early pregnancy and the risk of later GH/PE.
Participants were recruited and sampled in 10-14+6 weeks of gestation.
Definite GH/PE cases were matched 1 : 3 to controls with respect to age and gestational age.
Serum concentration of ELA was measured using enzyme immunoassay.
Women with later GH (N=28) had a slightly lower median concentration of ELA (46.72 ng/mL versus 53.54 ng/mL), while those with later PE (N=16) had a slightly higher median concentration of ELA (74.8 ng/mL versus 66.30 ng/mL) compared to the controls.
Yet, both the increments did not reach statistically significant difference (GH: P=0.380, PE: P=0.799).
ELA serum concentrations were unchanged in first trimester in women with GH/PE.
Further studies are still needed to identify the dynamic changes in serum ELA concentrations during the whole pregnancy, especially in those with pregnancy-induced hypertensive disorders.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ma, Shujuan& Guo, Chuhao& Zhang, Jiayue& Long, Sisi& Tan, Hongzhuan& You, Yiping. 2020. Association between ELABELA Serum Concentrations in First Trimester and Pregnancy-Induced Hypertension. BioMed Research International،Vol. 2020, no. 2020, pp.1-5.
https://search.emarefa.net/detail/BIM-1132259
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ma, Shujuan…[et al.]. Association between ELABELA Serum Concentrations in First Trimester and Pregnancy-Induced Hypertension. BioMed Research International No. 2020 (2020), pp.1-5.
https://search.emarefa.net/detail/BIM-1132259
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ma, Shujuan& Guo, Chuhao& Zhang, Jiayue& Long, Sisi& Tan, Hongzhuan& You, Yiping. Association between ELABELA Serum Concentrations in First Trimester and Pregnancy-Induced Hypertension. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-5.
https://search.emarefa.net/detail/BIM-1132259
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1132259
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر