Association between ELABELA Serum Concentrations in First Trimester and Pregnancy-Induced Hypertension
Joint Authors
Ma, Shujuan
Guo, Chuhao
Zhang, Jiayue
Long, Sisi
Tan, Hongzhuan
You, Yiping
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-09-28
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
ELABELA (ELA) is considered to be implicated in the pathophysiology of preeclampsia (PE), since ELA-deficient mice exhibited PE-like symptoms and infusion of exogenous ELA normalized the gestational hypertension (GH) and proteinuria.
However, no evidence show that circulating ELA is deficient in early placental development among women who destined to develop GH/PE.
This nested case-control study was conducted to investigate the association between serum ELA concentration in early pregnancy and the risk of later GH/PE.
Participants were recruited and sampled in 10-14+6 weeks of gestation.
Definite GH/PE cases were matched 1 : 3 to controls with respect to age and gestational age.
Serum concentration of ELA was measured using enzyme immunoassay.
Women with later GH (N=28) had a slightly lower median concentration of ELA (46.72 ng/mL versus 53.54 ng/mL), while those with later PE (N=16) had a slightly higher median concentration of ELA (74.8 ng/mL versus 66.30 ng/mL) compared to the controls.
Yet, both the increments did not reach statistically significant difference (GH: P=0.380, PE: P=0.799).
ELA serum concentrations were unchanged in first trimester in women with GH/PE.
Further studies are still needed to identify the dynamic changes in serum ELA concentrations during the whole pregnancy, especially in those with pregnancy-induced hypertensive disorders.
American Psychological Association (APA)
Ma, Shujuan& Guo, Chuhao& Zhang, Jiayue& Long, Sisi& Tan, Hongzhuan& You, Yiping. 2020. Association between ELABELA Serum Concentrations in First Trimester and Pregnancy-Induced Hypertension. BioMed Research International،Vol. 2020, no. 2020, pp.1-5.
https://search.emarefa.net/detail/BIM-1132259
Modern Language Association (MLA)
Ma, Shujuan…[et al.]. Association between ELABELA Serum Concentrations in First Trimester and Pregnancy-Induced Hypertension. BioMed Research International No. 2020 (2020), pp.1-5.
https://search.emarefa.net/detail/BIM-1132259
American Medical Association (AMA)
Ma, Shujuan& Guo, Chuhao& Zhang, Jiayue& Long, Sisi& Tan, Hongzhuan& You, Yiping. Association between ELABELA Serum Concentrations in First Trimester and Pregnancy-Induced Hypertension. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-5.
https://search.emarefa.net/detail/BIM-1132259
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1132259