Antiplatelet Aggregation, Cardiotonic, Anti-Inflammatory, Antioxidant, and Calcium Channel Antagonistic Potentials of Nepeta ruderalis Buch
المؤلفون المشاركون
Imran, Imran
Afzal, Khurram
Aleem, Ambreen
Wahid, Muqeet
Bibi, Sumbal
Mehmood, Rubada
Janbaz, Khalid Hussain
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-06-01
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
The objective of this study was to authenticate the ethnobotanical claims of the Nepeta ruderalis Buch.-Ham.
(N.
ruderalis) extract in the traditional system of medicine.
Crude extract was prepared via a simple maceration process.
DPPH free radical scavenging and carrageenan-induced rat paw edema models were used to monitor antioxidant and anti-inflammatory responses of the N.
ruderalis extract.
Furthermore, it was tested for antiplatelet aggregation, cardioprotective, and calcium channel antagonistic activities via standard documented protocols.
The N.
ruderalis extract exhibited 80.82% antioxidant activity (IC50=207.51±4.36 μg) while the anti-inflammatory response was significant (p<0.05 to p<0.01) at 50 mg/kg (45.58%) and 100 mg/kg (60.90%) doses.
Moreover, it was found to inhibit platelet aggregation (IC50=1.06 and 0.91 mg/mL) and, in addition, to increase the force of contraction at the concentration of 3.0-10 mg/mL with a decrease in the heart rate on isolated paired atria (EC50=11.78 mg/mL).
Relaxant activity was observed on the isolated rabbit jejunum (EC50=0.96 mg/mL) and trachea (EC50=0.89 mg/mL).
However, in a cumulative way, an 80-millimolar potassium-induced contraction was evaluated (EC50=1.31 mg/mL).
The N.
ruderalis extract exhibited antioxidant, anti-inflammatory, platelet aggregating, cardiotonic, and calcium channel antagonistic activities, therefore proving scientifically its effectiveness in the traditional system of medicine.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Aleem, Ambreen& Janbaz, Khalid Hussain& Imran, Imran& Wahid, Muqeet& Bibi, Sumbal& Afzal, Khurram…[et al.]. 2020. Antiplatelet Aggregation, Cardiotonic, Anti-Inflammatory, Antioxidant, and Calcium Channel Antagonistic Potentials of Nepeta ruderalis Buch. BioMed Research International،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1132320
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Aleem, Ambreen…[et al.]. Antiplatelet Aggregation, Cardiotonic, Anti-Inflammatory, Antioxidant, and Calcium Channel Antagonistic Potentials of Nepeta ruderalis Buch. BioMed Research International No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1132320
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Aleem, Ambreen& Janbaz, Khalid Hussain& Imran, Imran& Wahid, Muqeet& Bibi, Sumbal& Afzal, Khurram…[et al.]. Antiplatelet Aggregation, Cardiotonic, Anti-Inflammatory, Antioxidant, and Calcium Channel Antagonistic Potentials of Nepeta ruderalis Buch. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1132320
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1132320
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر