Antiplatelet Aggregation, Cardiotonic, Anti-Inflammatory, Antioxidant, and Calcium Channel Antagonistic Potentials of Nepeta ruderalis Buch
Joint Authors
Imran, Imran
Afzal, Khurram
Aleem, Ambreen
Wahid, Muqeet
Bibi, Sumbal
Mehmood, Rubada
Janbaz, Khalid Hussain
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-06-01
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The objective of this study was to authenticate the ethnobotanical claims of the Nepeta ruderalis Buch.-Ham.
(N.
ruderalis) extract in the traditional system of medicine.
Crude extract was prepared via a simple maceration process.
DPPH free radical scavenging and carrageenan-induced rat paw edema models were used to monitor antioxidant and anti-inflammatory responses of the N.
ruderalis extract.
Furthermore, it was tested for antiplatelet aggregation, cardioprotective, and calcium channel antagonistic activities via standard documented protocols.
The N.
ruderalis extract exhibited 80.82% antioxidant activity (IC50=207.51±4.36 μg) while the anti-inflammatory response was significant (p<0.05 to p<0.01) at 50 mg/kg (45.58%) and 100 mg/kg (60.90%) doses.
Moreover, it was found to inhibit platelet aggregation (IC50=1.06 and 0.91 mg/mL) and, in addition, to increase the force of contraction at the concentration of 3.0-10 mg/mL with a decrease in the heart rate on isolated paired atria (EC50=11.78 mg/mL).
Relaxant activity was observed on the isolated rabbit jejunum (EC50=0.96 mg/mL) and trachea (EC50=0.89 mg/mL).
However, in a cumulative way, an 80-millimolar potassium-induced contraction was evaluated (EC50=1.31 mg/mL).
The N.
ruderalis extract exhibited antioxidant, anti-inflammatory, platelet aggregating, cardiotonic, and calcium channel antagonistic activities, therefore proving scientifically its effectiveness in the traditional system of medicine.
American Psychological Association (APA)
Aleem, Ambreen& Janbaz, Khalid Hussain& Imran, Imran& Wahid, Muqeet& Bibi, Sumbal& Afzal, Khurram…[et al.]. 2020. Antiplatelet Aggregation, Cardiotonic, Anti-Inflammatory, Antioxidant, and Calcium Channel Antagonistic Potentials of Nepeta ruderalis Buch. BioMed Research International،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1132320
Modern Language Association (MLA)
Aleem, Ambreen…[et al.]. Antiplatelet Aggregation, Cardiotonic, Anti-Inflammatory, Antioxidant, and Calcium Channel Antagonistic Potentials of Nepeta ruderalis Buch. BioMed Research International No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1132320
American Medical Association (AMA)
Aleem, Ambreen& Janbaz, Khalid Hussain& Imran, Imran& Wahid, Muqeet& Bibi, Sumbal& Afzal, Khurram…[et al.]. Antiplatelet Aggregation, Cardiotonic, Anti-Inflammatory, Antioxidant, and Calcium Channel Antagonistic Potentials of Nepeta ruderalis Buch. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1132320
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1132320