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Optimization of Ultrasound-Assisted Extraction of Flavonoids from Celastrus hindsii Leaves Using Response Surface Methodology and Evaluation of Their Antioxidant and Antitumor Activities
المؤلفون المشاركون
Pham, Dinh-Chuong
Nguyen, Hoang-Chinh
Nguyen, Thanh-Hang Le
Ho, Hoang-Linh
Trinh, Thien-Kim
Riyaphan, Jirawat
Weng, Ching-Feng
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-02-15
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Celastrus hindsii is a potential source of flavonoids with biological activities.
This study aimed to develop an ultrasound-assisted technique for extracting flavonoids from leaves of C.
hindsii.
Response surface methodology was employed to optimize the extraction conditions for maximizing the total flavonoid content (TFC).
A maximum TFC of 23.6 mg QE/g was obtained under the extraction conditions of ultrasonic power of 130 W, extraction temperature of 40°C, extraction time of 29 min, and ethanol concentration of 65%.
The flavonoid-rich extracts were then studied for their antioxidant and anticancer activities.
The results showed that the C.
hindsii leaf extract exhibited potent radical scavenging activities against DPPH (IC50 of 164.85 μg/mL) and ABTS (IC50 of 89.05 μg/mL).
The extract also significantly inhibited the growth of 3 cancer cell lines MCF7, A549, and HeLa with the IC50 values of 88.1 μg/mL, 120.4 μg/mL, and 118.4 μg/mL, respectively.
Notably, the extract had no cytotoxicity effect on HK2 normal kidney cell line.
This study suggests that flavonoid-rich extract is a promising antioxidant and anticancer agent and that ultrasound-assisted extraction is an efficient method for extracting flavonoids from C.
hindsii leaves.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Pham, Dinh-Chuong& Nguyen, Hoang-Chinh& Nguyen, Thanh-Hang Le& Ho, Hoang-Linh& Trinh, Thien-Kim& Riyaphan, Jirawat…[et al.]. 2020. Optimization of Ultrasound-Assisted Extraction of Flavonoids from Celastrus hindsii Leaves Using Response Surface Methodology and Evaluation of Their Antioxidant and Antitumor Activities. BioMed Research International،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1133225
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Pham, Dinh-Chuong…[et al.]. Optimization of Ultrasound-Assisted Extraction of Flavonoids from Celastrus hindsii Leaves Using Response Surface Methodology and Evaluation of Their Antioxidant and Antitumor Activities. BioMed Research International No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1133225
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Pham, Dinh-Chuong& Nguyen, Hoang-Chinh& Nguyen, Thanh-Hang Le& Ho, Hoang-Linh& Trinh, Thien-Kim& Riyaphan, Jirawat…[et al.]. Optimization of Ultrasound-Assisted Extraction of Flavonoids from Celastrus hindsii Leaves Using Response Surface Methodology and Evaluation of Their Antioxidant and Antitumor Activities. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1133225
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1133225
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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