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Immune-Related Four-lncRNA Signature for Patients with Cervical Cancer
المؤلفون المشاركون
Zheng, Jianfeng
Cao, Benben
Zhang, Xia
Niu, Zheng
Tong, Jinyi
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-15، 15ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-11-16
دولة النشر
مصر
عدد الصفحات
15
التخصصات الرئيسية
الملخص EN
Cervical cancer (CC) is a common gynecological malignancy for which prognostic and therapeutic biomarkers are urgently needed.
The signature based on immune-related lncRNAs (IRLs) of CC has never been reported.
This study is aimed at establishing an IRL signature for patients with CC.
A cohort of 326 CC and 21 normal tissue samples with corresponding clinical information was included in this study.
Twenty-eight IRLs were collected according to the Pearson correlation analysis between the immune score and lncRNA expression (p<0.01).
Four IRLs (BZRAP1-AS1, EMX2OS, ZNF667-AS1, and CTC-429P9.1) with the most significant prognostic values (p<0.05) were identified which demonstrated an ability to stratify patients into the low-risk and high-risk groups by developing a risk score model.
It was observed that patients in the low-risk group showed longer overall survival (OS) than those in the high-risk group in the training set, valid set, and total set.
The area under the curve (AUC) of the receiver operating characteristic curve (ROC curve) for the four-IRL signature in predicting the one-, two-, and three-year survival rates was larger than 0.65.
In addition, the low-risk and high-risk groups displayed different immune statuses in GSEA.
These IRLs were also significantly correlated with immune cell infiltration.
Our results showed that the IRL signature had a prognostic value for CC.
Meanwhile, the specific mechanisms of the four IRLs in the development of CC were ascertained preliminarily.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zheng, Jianfeng& Cao, Benben& Zhang, Xia& Niu, Zheng& Tong, Jinyi. 2020. Immune-Related Four-lncRNA Signature for Patients with Cervical Cancer. BioMed Research International،Vol. 2020, no. 2020, pp.1-15.
https://search.emarefa.net/detail/BIM-1133366
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zheng, Jianfeng…[et al.]. Immune-Related Four-lncRNA Signature for Patients with Cervical Cancer. BioMed Research International No. 2020 (2020), pp.1-15.
https://search.emarefa.net/detail/BIM-1133366
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zheng, Jianfeng& Cao, Benben& Zhang, Xia& Niu, Zheng& Tong, Jinyi. Immune-Related Four-lncRNA Signature for Patients with Cervical Cancer. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-15.
https://search.emarefa.net/detail/BIM-1133366
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1133366
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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